TY - JOUR
T1 - Causative role of oxyradicals in myocardial stunning
T2 - A proven hypothesis. A brief review of the evidence demonstrating a major role of reactive oxygen species in several forms of postischemic dysfunction
AU - Bolli, R.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1998/6
Y1 - 1998/6
N2 - Whether or not ROS are the actual initiator or a downstream mediator of stunning, the theory that they play a major causative role in this phenomenon is now a proven hypothesis. ROS play a prominent role in multiple forms of stunning. Furthermore, the role of ROS is prominent not only in open-chest models but also in conscious animal preparations. The major challenge for future studies will be to identify the specific molecular targets of ROS-mediated damage and to decipher the pathways whereby ROS and calcium interact in the genesis of myocardial stunning.
AB - Whether or not ROS are the actual initiator or a downstream mediator of stunning, the theory that they play a major causative role in this phenomenon is now a proven hypothesis. ROS play a prominent role in multiple forms of stunning. Furthermore, the role of ROS is prominent not only in open-chest models but also in conscious animal preparations. The major challenge for future studies will be to identify the specific molecular targets of ROS-mediated damage and to decipher the pathways whereby ROS and calcium interact in the genesis of myocardial stunning.
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U2 - 10.1007/s003950050079
DO - 10.1007/s003950050079
M3 - Article
C2 - 9689438
AN - SCOPUS:0031849502
SN - 0300-8428
VL - 93
SP - 156
EP - 162
JO - Basic Research in Cardiology
JF - Basic Research in Cardiology
IS - 3
ER -