The reported link between SV40 and mesothelioma is questionable. The most recent studies do not confirm the previous reports of SV40 sequences in mesothelioma tissues, and one study raises the possibility that contamination with common laboratory plasmids may account for some of the previous data. Individuals exposed to SV40 in contaminated vaccines have not been shown to be at increased risk for mesothelioma. With SV40 and mesothelioma, the data on viral sequences in tumors are inconsistent and disputed, and serologic evidence does not support any association. The epidemiologic data do not show that documented exposures to SV40 increase the risk of mesothelioma. It seems unlikely that infection with SV40 contributes to the development of human mesothelioma or of any other human cancer.
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine