Causal scale of rotors in a cardiac system

Hiroshi Ashikaga, Francisco Prieto-Castrillo, Mari Kawakatsu, Nima Dehghani

Research output: Contribution to journalArticle

Abstract

Rotors of spiral waves are thought to be one of the potential mechanisms that maintain atrial fibrillation (AF). However, disappointing clinical outcomes of rotor mapping and ablation to eliminate AF raise a serious doubt on rotors as a macro-scale mechanism that causes the micro-scale behavior of individual cardiomyocytes to maintain spiral waves. In this study, we aimed to elucidate the causal relationship between rotors and spiral waves in a numerical model of cardiac excitation. To accomplish the aim, we described the system in a series of spatiotemporal scales by generating a renormalization group, and evaluated the causal architecture of the system by quantifying causal emergence. Causal emergence is an information-theoretic metric that quantifies emergence or reduction between micro- and macro-scale behaviors of a system by evaluating effective information at each scale. We found that the cardiac system with rotors has a spatiotemporal scale at which effective information peaks. A positive correlation between the number of rotors and causal emergence was observed only up to the scale of peak causation. We conclude that rotors are not the universal mechanism to maintain spiral waves at all spatiotemporal scales. This finding may account for the conflicting benefit of rotor ablation in clinical studies.

Original languageEnglish (US)
Article number30
JournalFrontiers in Physics
Volume6
Issue numberAPR
DOIs
StatePublished - Apr 10 2018

Fingerprint

Cardiac
Atrial Fibrillation
Rotor
rotors
Rotors
Spiral Wave
Cardiac Myocytes
Causality
fibrillation
Ablation
Macros
ablation
Causation
Renormalization Group
Numerical models
Quantify
Eliminate
Excitation
Metric
Series

Keywords

  • Atrial fibrillation
  • Cardiac dynamics
  • Complex systems
  • Information theory
  • Rotors

ASJC Scopus subject areas

  • Biophysics
  • Materials Science (miscellaneous)
  • Mathematical Physics
  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Cite this

Ashikaga, H., Prieto-Castrillo, F., Kawakatsu, M., & Dehghani, N. (2018). Causal scale of rotors in a cardiac system. Frontiers in Physics, 6(APR), [30]. https://doi.org/10.3389/fphy.2018.00030

Causal scale of rotors in a cardiac system. / Ashikaga, Hiroshi; Prieto-Castrillo, Francisco; Kawakatsu, Mari; Dehghani, Nima.

In: Frontiers in Physics, Vol. 6, No. APR, 30, 10.04.2018.

Research output: Contribution to journalArticle

Ashikaga, H, Prieto-Castrillo, F, Kawakatsu, M & Dehghani, N 2018, 'Causal scale of rotors in a cardiac system', Frontiers in Physics, vol. 6, no. APR, 30. https://doi.org/10.3389/fphy.2018.00030
Ashikaga H, Prieto-Castrillo F, Kawakatsu M, Dehghani N. Causal scale of rotors in a cardiac system. Frontiers in Physics. 2018 Apr 10;6(APR). 30. https://doi.org/10.3389/fphy.2018.00030
Ashikaga, Hiroshi ; Prieto-Castrillo, Francisco ; Kawakatsu, Mari ; Dehghani, Nima. / Causal scale of rotors in a cardiac system. In: Frontiers in Physics. 2018 ; Vol. 6, No. APR.
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