Caudal hindbrain neuromedin B-preferring receptors participate in the control of food intake

E. E. Ladenheim, J. E. Taylor, D. H. Coy, T. S. Carrigan, A. Wohn, T. H. Moran

Research output: Contribution to journalArticle

Abstract

Recent studies have identified two subtypes of bombesin (BN) receptors in the rat central nervous system: gastrin releasing-peptide (GRP) preferring and neuromedin B (NMB) preferring. To investigate a role for the NMB- preferring receptor subtype in feeding suppression elicited by fourth ventricular (4V) BN administration, we evaluated the ability of a selective NMB-preferring receptor antagonist, BIM-23127, to block suppression of glucose intake produced by 4V BN (10 pmol). Our results showed that 4V administration of BIM-23127 dose dependently antagonized the suppression of glucose intake produced by 4V BN. In addition, 4V administration of BIM- 23127 alone increased glucose intake above that observed in the baseline condition. These results support a role for the NMB-preferring BN receptor subtype in the suppression of intake produced by 4V BN administration and suggest that endogenously released NMB participates in ingestive control.

Original languageEnglish (US)
Pages (from-to)R433-R437
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume272
Issue number1 41-1
StatePublished - Feb 20 1997

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Keywords

  • bombesin
  • caudal brain stem

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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