Abstract
Vertebrate photoreceptors respond to light by a membrane hyperpolarization which is thought to result from the decrease of a Na-selective conductance in the outer segment1-6. One hypothesis is that light increases intracellular free Ca which reversibly blocks the Na conductance7,8; at least part of this Ca is then extruded to the cell exterior by a Na-Ca exchanger at the plasma membrane9-14. We describe experiments here which show that the light-sensitive conductance in rods is also highly permeable to K. While external Na acts to keep the conductance open, external K tends to keep it closed, both actions probably involving the Na-Ca exchanger. The conductance is also permeable to the monovalent cations Li, Rb and Cs and the divalent cations Ca, Sr and Ba. The ability of both Na and K to go through the light-sensitive conductance explains the long-standing puzzle as to why the reversal potential for the light response is at 0 to +10 mV15-17.
Original language | English (US) |
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Pages (from-to) | 352-354 |
Number of pages | 3 |
Journal | Nature |
Volume | 309 |
Issue number | 5966 |
DOIs | |
State | Published - 1984 |
Externally published | Yes |
ASJC Scopus subject areas
- General