Catheter-directed thrombolysis of inferior vena cava thrombosis in a 13-day-old neonate and review of literature

Jawad U. Khan, Clifford M. Takemoto, James F. Casella, Michael B. Streiff, Ikechi J. Nwankwo, Hyun S. Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Complete inferior vena cava thrombosis (IVC) in neonates is uncommon, but may cause significant morbidity. A 13-day-old neonate suffered IVC thrombosis secondary to antithrombin III deficiency, possibly contributed to by a mutation in the methyl tetrahydrofolate reductase gene. Catheter-directed thrombolysis (CDT) with recombinant tissue plasminogen activator (rt-PA, Alteplase) was used successfully to treat extensive venous thrombosis in this neonate without complications. We also review the literature on CDT for treatment of IVC thrombosis in critically ill neonates and infants.

Original languageEnglish (US)
Pages (from-to)S153-S160
JournalCardiovascular and interventional radiology
Volume31
Issue numberSUPPL.2
DOIs
StatePublished - Jul 1 2008

Keywords

  • Catheter-directed thrombolysis
  • Inferior vena cava thrombosis
  • Neonate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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