TY - JOUR
T1 - Catheter-directed gastric artery chemical embolization suppresses systemic ghrelin levels in porcine model
AU - Arepally, Aravind
AU - Barnett, Brad P.
AU - Patel, Tarek T.
AU - Howland, Valerie
AU - Boston, Ray C.
AU - Kraitchman, Dara L.
AU - Akhavan Malayeri, Ashkan
PY - 2008/10
Y1 - 2008/10
N2 - Purpose: To prospectively test, in a porcine model, the hypothesis that catheter-directed gastric artery chemical embolization (GACE) can result in suppression of systemic ghrelin levels and affect weight gain. Materials and This study, which had Animal Care and Use Committee Methods: approval, was performed in healthy, growing swine (weight range, 40-45 kg; n = 10). GACE was performed in five swine with the infusion of sodium morrhuate (125 (ig) selectively into the gastric arteries that supply the fundus. Five control animals underwent a sham procedure with 5 mL of saline. Weight and fasting plasma ghrelin levels were obtained in animals at baseline and in weeks 1-4. Statistical testing for substantial differences in ghrelin blood levels over time and between treated and untreated animals was performed by using a cross-sectional timeseries linear model with feasibility generalized least squares. Results: The pattern of the change in ghrelin levels over time was significantly different between control and treated animals (P < .004). In treated animals, ghrelin levels were significantly reduced at week 1 (mean, 664.1 pg/mL ± 103.1 [standard error of the mean], P < .02), week 2 (mean, 618.1 pg/mL ± 180.4, P < .001), week 3 (mean, 578.4 pg/mL ± 214.9, P < .001), and week 4 (mean, 876.6 pg/mL ± 228.6, P < .03) relative to baseline (mean, 1006.3 pg/mL ± 190.1). The percentage change in serum ghrelin values in swine treated with GACE decreased from baseline to -34%, -38.6%, -42.5%, and -12.9% during weeks 1- 4, respectively. In control swine, percentage change in serum ghrelin was -1.7%, -9.7%, +2.6%, and + 18.2% during weeks 1-4, respectively. At the end of 4 weeks, control swine continued to gain weight, with a 15.1% increase from their original weight, while the weight in swine treated with GACE plateaued at an increase of 7.8% from the original weight. Conclusion: Catheter-directed GACE can suppress the appetite hormone ghrelin and affect weight gain.
AB - Purpose: To prospectively test, in a porcine model, the hypothesis that catheter-directed gastric artery chemical embolization (GACE) can result in suppression of systemic ghrelin levels and affect weight gain. Materials and This study, which had Animal Care and Use Committee Methods: approval, was performed in healthy, growing swine (weight range, 40-45 kg; n = 10). GACE was performed in five swine with the infusion of sodium morrhuate (125 (ig) selectively into the gastric arteries that supply the fundus. Five control animals underwent a sham procedure with 5 mL of saline. Weight and fasting plasma ghrelin levels were obtained in animals at baseline and in weeks 1-4. Statistical testing for substantial differences in ghrelin blood levels over time and between treated and untreated animals was performed by using a cross-sectional timeseries linear model with feasibility generalized least squares. Results: The pattern of the change in ghrelin levels over time was significantly different between control and treated animals (P < .004). In treated animals, ghrelin levels were significantly reduced at week 1 (mean, 664.1 pg/mL ± 103.1 [standard error of the mean], P < .02), week 2 (mean, 618.1 pg/mL ± 180.4, P < .001), week 3 (mean, 578.4 pg/mL ± 214.9, P < .001), and week 4 (mean, 876.6 pg/mL ± 228.6, P < .03) relative to baseline (mean, 1006.3 pg/mL ± 190.1). The percentage change in serum ghrelin values in swine treated with GACE decreased from baseline to -34%, -38.6%, -42.5%, and -12.9% during weeks 1- 4, respectively. In control swine, percentage change in serum ghrelin was -1.7%, -9.7%, +2.6%, and + 18.2% during weeks 1-4, respectively. At the end of 4 weeks, control swine continued to gain weight, with a 15.1% increase from their original weight, while the weight in swine treated with GACE plateaued at an increase of 7.8% from the original weight. Conclusion: Catheter-directed GACE can suppress the appetite hormone ghrelin and affect weight gain.
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U2 - 10.1148/radiol.2491071232
DO - 10.1148/radiol.2491071232
M3 - Article
C2 - 18796671
AN - SCOPUS:53749092335
VL - 249
SP - 127
EP - 133
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 1
ER -