Catheter-based endomyocardial injection with real-time magnetic resonance imaging

Robert J. Lederman; Michael A. Guttman; Dana C. Peters; Richard B. Thompson; Jonathan M. Sorger; Alexander J. Dick; Venkatesh K. Raman; Elliot R. McVeigh

doi:10.1161/circ.105.11.1282

Catheter-based endomyocardial injection with real-time magnetic resonance imaging

Robert J. Lederman, Michael A. Guttman, Dana C. Peters, Richard B. Thompson, Jonathan M. Sorger, Alexander J. Dick, Venkatesh K. Raman, Elliot R. McVeigh

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

Background - We tested the feasibility of targeted left ventricular (LV) mural injection using real-time MRI (rtMRI). Methods and Results - A 1.5T MRI scanner was customized with a fast reconstruction engine, transfemoral guiding catheter-receiver coil (GCC), MRI-compatible needle, and tableside consoles. Commercial real-time imaging software was customized to facilitate catheter navigation and visualization of injections at 4 completely refreshed frames per second. The aorta was traversed and the left ventricular cavity was entered under direct rtMRI guidance. Pigs underwent multiple injections with dilute gadolinium-DTPA. All myocardial segments were readily accessed. The active GCC and the passive Stiletto needle injector were readily visualized. More than 50 endomyocardial injections were performed with the aid of rtMRI; 81% were successful with this first-generation prototype. Conclusion - Percutaneous endomyocardial drug delivery is feasible with the aid of rtMRI, which permits precise 3-dimensional localization of injection within the LV wall.

Original language	English (US)
Pages (from-to)	1282-1284
Number of pages	3
Journal	Circulation
Volume	105
Issue number	11
DOIs	https://doi.org/10.1161/circ.105.11.1282
State	Published - Mar 19 2002
Externally published	Yes

Keywords

Catheterization
Drugs
Ischemia
Magnetic resonance imaging
Radiography

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1161/circ.105.11.1282

Cite this

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title = "Catheter-based endomyocardial injection with real-time magnetic resonance imaging",

abstract = "Background - We tested the feasibility of targeted left ventricular (LV) mural injection using real-time MRI (rtMRI). Methods and Results - A 1.5T MRI scanner was customized with a fast reconstruction engine, transfemoral guiding catheter-receiver coil (GCC), MRI-compatible needle, and tableside consoles. Commercial real-time imaging software was customized to facilitate catheter navigation and visualization of injections at 4 completely refreshed frames per second. The aorta was traversed and the left ventricular cavity was entered under direct rtMRI guidance. Pigs underwent multiple injections with dilute gadolinium-DTPA. All myocardial segments were readily accessed. The active GCC and the passive Stiletto needle injector were readily visualized. More than 50 endomyocardial injections were performed with the aid of rtMRI; 81% were successful with this first-generation prototype. Conclusion - Percutaneous endomyocardial drug delivery is feasible with the aid of rtMRI, which permits precise 3-dimensional localization of injection within the LV wall.",

keywords = "Catheterization, Drugs, Ischemia, Magnetic resonance imaging, Radiography",

author = "Lederman, {Robert J.} and Guttman, {Michael A.} and Peters, {Dana C.} and Thompson, {Richard B.} and Sorger, {Jonathan M.} and Dick, {Alexander J.} and Raman, {Venkatesh K.} and McVeigh, {Elliot R.}",

year = "2002",

month = mar,

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doi = "10.1161/circ.105.11.1282",

language = "English (US)",

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T1 - Catheter-based endomyocardial injection with real-time magnetic resonance imaging

AU - Lederman, Robert J.

AU - Guttman, Michael A.

AU - Peters, Dana C.

AU - Thompson, Richard B.

AU - Sorger, Jonathan M.

AU - Dick, Alexander J.

AU - Raman, Venkatesh K.

AU - McVeigh, Elliot R.

PY - 2002/3/19

Y1 - 2002/3/19

N2 - Background - We tested the feasibility of targeted left ventricular (LV) mural injection using real-time MRI (rtMRI). Methods and Results - A 1.5T MRI scanner was customized with a fast reconstruction engine, transfemoral guiding catheter-receiver coil (GCC), MRI-compatible needle, and tableside consoles. Commercial real-time imaging software was customized to facilitate catheter navigation and visualization of injections at 4 completely refreshed frames per second. The aorta was traversed and the left ventricular cavity was entered under direct rtMRI guidance. Pigs underwent multiple injections with dilute gadolinium-DTPA. All myocardial segments were readily accessed. The active GCC and the passive Stiletto needle injector were readily visualized. More than 50 endomyocardial injections were performed with the aid of rtMRI; 81% were successful with this first-generation prototype. Conclusion - Percutaneous endomyocardial drug delivery is feasible with the aid of rtMRI, which permits precise 3-dimensional localization of injection within the LV wall.

AB - Background - We tested the feasibility of targeted left ventricular (LV) mural injection using real-time MRI (rtMRI). Methods and Results - A 1.5T MRI scanner was customized with a fast reconstruction engine, transfemoral guiding catheter-receiver coil (GCC), MRI-compatible needle, and tableside consoles. Commercial real-time imaging software was customized to facilitate catheter navigation and visualization of injections at 4 completely refreshed frames per second. The aorta was traversed and the left ventricular cavity was entered under direct rtMRI guidance. Pigs underwent multiple injections with dilute gadolinium-DTPA. All myocardial segments were readily accessed. The active GCC and the passive Stiletto needle injector were readily visualized. More than 50 endomyocardial injections were performed with the aid of rtMRI; 81% were successful with this first-generation prototype. Conclusion - Percutaneous endomyocardial drug delivery is feasible with the aid of rtMRI, which permits precise 3-dimensional localization of injection within the LV wall.

KW - Catheterization

KW - Drugs

KW - Ischemia

KW - Magnetic resonance imaging

KW - Radiography

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JO - Circulation

JF - Circulation

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ER -

Catheter-based endomyocardial injection with real-time magnetic resonance imaging

Abstract

Keywords

ASJC Scopus subject areas

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