Catheter-based endomyocardial injection with real-time magnetic resonance imaging

Robert J. Lederman, Michael A. Guttman, Dana C. Peters, Richard B. Thompson, Jonathan M. Sorger, Alexander J. Dick, Venkatesh K. Raman, Elliot R. McVeigh

Research output: Contribution to journalArticlepeer-review

Abstract

Background - We tested the feasibility of targeted left ventricular (LV) mural injection using real-time MRI (rtMRI). Methods and Results - A 1.5T MRI scanner was customized with a fast reconstruction engine, transfemoral guiding catheter-receiver coil (GCC), MRI-compatible needle, and tableside consoles. Commercial real-time imaging software was customized to facilitate catheter navigation and visualization of injections at 4 completely refreshed frames per second. The aorta was traversed and the left ventricular cavity was entered under direct rtMRI guidance. Pigs underwent multiple injections with dilute gadolinium-DTPA. All myocardial segments were readily accessed. The active GCC and the passive Stiletto needle injector were readily visualized. More than 50 endomyocardial injections were performed with the aid of rtMRI; 81% were successful with this first-generation prototype. Conclusion - Percutaneous endomyocardial drug delivery is feasible with the aid of rtMRI, which permits precise 3-dimensional localization of injection within the LV wall.

Original languageEnglish (US)
Pages (from-to)1282-1284
Number of pages3
JournalCirculation
Volume105
Issue number11
DOIs
StatePublished - Mar 19 2002

Keywords

  • Catheterization
  • Drugs
  • Ischemia
  • Magnetic resonance imaging
  • Radiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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