Cisteínoproteasas catepsinas l de taenia solium: Rol biológico en la infección y potencial uso para el inmunodiagnóstico de la neurocisticercosis

Translated title of the contribution: Cathepsin l cysteine protease from Taenia solium: Its biological role in the infection and potential use for the immunodiagnosis of neurocysticercosis

Nancy León, Carlos Padilla, Mónica Pajuelo, Patricia Sheen, Mirko Zimic

Research output: Contribution to journalArticlepeer-review

Abstract

Taenia solium is a plane helminth responsible for taeniasis and human cysticercosis, the latter being the result of the consumption of infective eggs. Cysticerci can develop in different human tissues, often in the central nervous system, causing neurocysticercosis (NCC). For the diagnosis of NCC, an adequate interpretation of clinical data, neuroimaging results and serological tests are required. However, serological tests could be improved by developing candidate antigens able to increase their sensibility and specificity. In the last years, a series of surface and secretory proteins of T. solium essential for the parasite-host interaction have been described. One of these families is cathepsin L cysteine proteases, which have a predominant role in the development and survival of the parasite. They take part in the tissue invasion, immune response evasion, excystation and encystment of cysticercus. They are considered potential antigens for the immunodiagnosis of neurocysticercosis.

Translated title of the contributionCathepsin l cysteine protease from Taenia solium: Its biological role in the infection and potential use for the immunodiagnosis of neurocysticercosis
Original languageSpanish
Pages (from-to)446-454
Number of pages9
JournalRevista Peruana de Medicina Experimental y Salud Publica
Volume30
Issue number3
StatePublished - Jan 1 2013
Externally publishedYes

Keywords

  • Cathepsin L
  • Host-parasite interactions
  • Immunologic tests
  • Neurocysticercosis
  • Taenia solium

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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