Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population

A. Payton, F. Holland, P. Diggle, P. Rabbitt, M. Horan, Y. Davidson, L. Gibbons, J. Worthington, W. E R Ollier, N. Pendleton

Research output: Contribution to journalArticle

Abstract

General intelligence is a heritable trait that is a risk factor for both the onset of dementia and the rate of cognitive decline in community-dwelling older persons. Previous studies screening for quantitative trait loci (QTLs) that influence general intelligence in healthy individuals have identified four loci, two of which are located within the genes insulin-like growth factor 2 receptor (IGF2R) and the Msx1 homeobox. Here, we report the finding of another QTL associated with general intelligence that is located within exon 2 of the cathepsin D (CTSD) gene. A group of 767 healthy adults with a follow-up period of over 15 years have been analyzed for cross-sectional and longitudinal trends in cognitive change using the Heim intelligence test score (AH4-1). We observed a significant association (P=0.01) between a functional C>T (Ala>Val) transition within exon 2 of the CTSD gene that increases the secretion of pro-CTSD from the cell, and the AH4-1 score at initial testing on entry to the longitudinal study. Interestingly, CTSD is transported by IGF2R from the trans Golgi network to the lysosome.

Original languageEnglish (US)
Pages (from-to)14-18
Number of pages5
JournalMolecular Psychiatry
Volume8
Issue number1
DOIs
StatePublished - 2003
Externally publishedYes

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Keywords

  • Association
  • Cathepsin D
  • Cognitive decline
  • Intelligence
  • Polymorphism

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health

Cite this

Payton, A., Holland, F., Diggle, P., Rabbitt, P., Horan, M., Davidson, Y., Gibbons, L., Worthington, J., Ollier, W. E. R., & Pendleton, N. (2003). Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population. Molecular Psychiatry, 8(1), 14-18. https://doi.org/10.1038/sj.mp.4001239