Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates

C. A. Kitt, R. G. Struble, L. C. Cork, W. C. Mobley, L. C. Walker, T. H. Joh, D. L. Price

Research output: Contribution to journalArticle

Abstract

Immunocytochemical studies, using a polyclonal antibody directed against tyrosine hydroxylase, identified catecholaminergic axons in prefrontal cortex of young and aged nonhuman primates. Aged monkeys, who showed cortical senile plaques in silver stains, had swollen tyrosine hydroxylase-immunoreactive axons in neocortex. Some of these abnormal processes were associated with deposits of amyloid (visualized by thioflavin-T fluorescence) and were similar in appearance to neurites demonstrated by silver impregnation methods. This study provides evidence for structural abnormalities in catecholaminergic axons/nerve terminals in the neocortices of aged primates.

Original languageEnglish (US)
Pages (from-to)691-695,697-699
JournalNeuroscience
Volume16
Issue number3
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Neuroscience(all)

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    Kitt, C. A., Struble, R. G., Cork, L. C., Mobley, W. C., Walker, L. C., Joh, T. H., & Price, D. L. (1985). Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates. Neuroscience, 16(3), 691-695,697-699. https://doi.org/10.1016/0306-4522(85)90202-7