Catalytic subunit of human telomerase reverse transcriptase is an independent predictor of survival in patients undergoing curative resection of hepatic colorectal metastases: A multicenter analysis

Julien Dômont, Timothy M. Pawlik, Valérie Boige, Mathieu Rose, Jean Christophe Weber, Paulo M. Hoff, Thomas D. Brown, Daria Zorzi, Luc Morat, Jean Pierre Pignon, Asif Rashid, Daniel Jaeck, Laure Sabatier, Dominique Elias, Thomas Tursz, Jean Charles Soria, Jean Nicolas Vauthey

Research output: Contribution to journalArticle

Abstract

Purpose: To determine the role of the catalytic subunit of human telomerase reverse transcriptase (hTERT) in predicting survival after resection of hepatic colorectal metastases (CRM). Patients and Methods: Two hundred one patients who underwent curative resection of hepatic CRM between 1990 and 2000 were identified from a multicenter database. The CRM were analyzed for hTERT nucleolar expression by standard immunohistochemical techniques. hTERT expression and known clinicopathologic factors of survival were examined. Results: With a median follow-up of 80 months, 152 patients (75.6%) had died; the 5-year overall survival was 30.7%. On univariate analysis, number of metastases greater than two (P = .0005), extrahepatic disease (P = .0054), disease-free interval less than 12 months (P = .006), carcinoembryonic antigen level greater than 200 ng/mL (P = .0071), and positive hTERT nucleolar staining (P <.0001) were associated with decreased survival. On multivariate analysis, three factors independently predicted survival: number of metastases (relative risk [RR] = 1.74; P = .0011); disease-free interval (RR = 1.70; P = .0035); and positive hTERT nucleolar staining (RR = 2.03; P <.0001). Patients with none or one of these factors had a 5-year survival rate of 48%, whereas those with two or three of these factors had a 5-year survival of 15% (P <.0001). Conclusion: hTERT nucleolar expression is associated with worse survival after resection of hepatic CRM. hTERT expression in conjunction with number of hepatic metastases and disease-free interval may permit more accurate prediction of survival after resection of hepatic CRM.

Original languageEnglish (US)
Pages (from-to)3086-3093
Number of pages8
JournalJournal of Clinical Oncology
Volume23
Issue number13
DOIs
StatePublished - 2005
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Dômont, J., Pawlik, T. M., Boige, V., Rose, M., Weber, J. C., Hoff, P. M., Brown, T. D., Zorzi, D., Morat, L., Pignon, J. P., Rashid, A., Jaeck, D., Sabatier, L., Elias, D., Tursz, T., Soria, J. C., & Vauthey, J. N. (2005). Catalytic subunit of human telomerase reverse transcriptase is an independent predictor of survival in patients undergoing curative resection of hepatic colorectal metastases: A multicenter analysis. Journal of Clinical Oncology, 23(13), 3086-3093. https://doi.org/10.1200/JCO.2005.06.944