@inbook{46e6b3b975a44bdda6544c1c50098548,
title = "Catalytic mechanisms and regulation of protein kinases",
abstract = "Protein kinases transfer a phosphoryl group from ATP onto target proteins and play a critical role in signal transduction and other cellular processes. Here, we review the kinase kinetic and chemical mechanisms and their application in understanding kinase structure and function. Aberrant kinase activity has been implicated in many human diseases, in particular cancer. We highlight applications of technologies and concepts derived from kinase mechanistic studies that have helped illuminate how kinases are regulated and contribute to pathophysiology.",
keywords = "B-Raf, Bisubstrate analog, Chemical rescue, EGFR, Erlotinib, Inhibitor, Lapatinib, Src, Transition state",
author = "Zhihong Wang and Cole, {Philip A.}",
note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Inc. All rights reserved.",
year = "2014",
doi = "10.1016/B978-0-12-397918-6.00001-X",
language = "English (US)",
series = "Methods in Enzymology",
publisher = "Academic Press Inc.",
number = "C",
pages = "1--21",
booktitle = "Methods in Enzymology",
edition = "C",
}