Ca2+ sensors of L-type Ca2+ channel

Christoph Romanin, Roland Gamsjaeger, Heike Kahr, Daniela Schaufler, Olga Carlson, Darrell R. Abernethy, Nikolai M. Soldatov

Research output: Contribution to journalArticle

Abstract

Ca2+-induced inactivation of L-type Ca2+ is differentially mediated by two C-terminal motifs of the α1C subunit, L (1572-1587) and K (1599-1651) implicated for calmodulin binding. We found that motif L is composed of a highly selective Ca2+ sensor and an adjacent Ca2+-independent tethering site for calmodulin. The Ca2+ sensor contributes to higher Ca2+ sensitivity of the motif L complex with calmodulin. Since only combined mutation of both sites removes Ca2+-dependent current decay, the two-site modulation by Ca2+ and calmodulin may underlie Ca2+-induced inactivation of the channel.

Original languageEnglish (US)
Pages (from-to)301-306
Number of pages6
JournalFEBS Letters
Volume487
Issue number2
DOIs
StatePublished - Dec 29 2000

Keywords

  • Ca sensor
  • Calcium channel
  • Calmodulin
  • Heart
  • Inactivation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Romanin, C., Gamsjaeger, R., Kahr, H., Schaufler, D., Carlson, O., Abernethy, D. R., & Soldatov, N. M. (2000). Ca2+ sensors of L-type Ca2+ channel. FEBS Letters, 487(2), 301-306. https://doi.org/10.1016/S0014-5793(00)02361-9