Caspofungin for the treatment of azole resistant candidemia in a premature infant

P. B. Smith; W. J. Steinbach; C. M. Cotten; W. A. Schell; J. R. Perfect; T. J. Walsh; D. K. Benjamin

doi:10.1038/sj.jp.7211637

Caspofungin for the treatment of azole resistant candidemia in a premature infant

P. B. Smith, W. J. Steinbach, C. M. Cotten, W. A. Schell, J. R. Perfect, T. J. Walsh, D. K. Benjamin

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Candidemia is common in extremely low birth weight infants and is associated with substantial mortality and morbidity. Treatment options have traditionally been limited to amphotericin B deoxycholate or fluconazole. We present a case of a premature infant with persistent candidemia despite antifungal treatment that responded to therapy with caspofungin, an echinocandin antifungal. The infant's Candida isolate developed resistance to azoles during fluconazole administration and also suffered from severe hypercalcemia during the initiation of caspofungin therapy.

Original language	English (US)
Pages (from-to)	127-129
Number of pages	3
Journal	Journal of Perinatology
Volume	27
Issue number	2
DOIs	https://doi.org/10.1038/sj.jp.7211637
State	Published - Feb 2007
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

Access to Document

10.1038/sj.jp.7211637

Cite this

@article{a436273e06da4749bfdde5daed5e7a25,

title = "Caspofungin for the treatment of azole resistant candidemia in a premature infant",

abstract = "Candidemia is common in extremely low birth weight infants and is associated with substantial mortality and morbidity. Treatment options have traditionally been limited to amphotericin B deoxycholate or fluconazole. We present a case of a premature infant with persistent candidemia despite antifungal treatment that responded to therapy with caspofungin, an echinocandin antifungal. The infant's Candida isolate developed resistance to azoles during fluconazole administration and also suffered from severe hypercalcemia during the initiation of caspofungin therapy.",

author = "Smith, {P. B.} and Steinbach, {W. J.} and Cotten, {C. M.} and Schell, {W. A.} and Perfect, {J. R.} and Walsh, {T. J.} and Benjamin, {D. K.}",

year = "2007",

month = feb,

doi = "10.1038/sj.jp.7211637",

language = "English (US)",

volume = "27",

pages = "127--129",

journal = "Journal of Perinatology",

issn = "0743-8346",

publisher = "Nature Publishing Group",

number = "2",

}

TY - JOUR

T1 - Caspofungin for the treatment of azole resistant candidemia in a premature infant

AU - Smith, P. B.

AU - Steinbach, W. J.

AU - Cotten, C. M.

AU - Schell, W. A.

AU - Perfect, J. R.

AU - Walsh, T. J.

AU - Benjamin, D. K.

PY - 2007/2

Y1 - 2007/2

N2 - Candidemia is common in extremely low birth weight infants and is associated with substantial mortality and morbidity. Treatment options have traditionally been limited to amphotericin B deoxycholate or fluconazole. We present a case of a premature infant with persistent candidemia despite antifungal treatment that responded to therapy with caspofungin, an echinocandin antifungal. The infant's Candida isolate developed resistance to azoles during fluconazole administration and also suffered from severe hypercalcemia during the initiation of caspofungin therapy.

AB - Candidemia is common in extremely low birth weight infants and is associated with substantial mortality and morbidity. Treatment options have traditionally been limited to amphotericin B deoxycholate or fluconazole. We present a case of a premature infant with persistent candidemia despite antifungal treatment that responded to therapy with caspofungin, an echinocandin antifungal. The infant's Candida isolate developed resistance to azoles during fluconazole administration and also suffered from severe hypercalcemia during the initiation of caspofungin therapy.

UR - http://www.scopus.com/inward/record.url?scp=33846662105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846662105&partnerID=8YFLogxK

U2 - 10.1038/sj.jp.7211637

DO - 10.1038/sj.jp.7211637

M3 - Article

C2 - 17262048

AN - SCOPUS:33846662105

SN - 0743-8346

VL - 27

SP - 127

EP - 129

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 2

ER -

Caspofungin for the treatment of azole resistant candidemia in a premature infant

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this