Caspofungin for the treatment of azole resistant candidemia in a premature infant

P. B. Smith, W. J. Steinbach, C. M. Cotten, W. A. Schell, J. R. Perfect, T. J. Walsh, D. K. Benjamin

Research output: Contribution to journalArticlepeer-review


Candidemia is common in extremely low birth weight infants and is associated with substantial mortality and morbidity. Treatment options have traditionally been limited to amphotericin B deoxycholate or fluconazole. We present a case of a premature infant with persistent candidemia despite antifungal treatment that responded to therapy with caspofungin, an echinocandin antifungal. The infant's Candida isolate developed resistance to azoles during fluconazole administration and also suffered from severe hypercalcemia during the initiation of caspofungin therapy.

Original languageEnglish (US)
Pages (from-to)127-129
Number of pages3
JournalJournal of Perinatology
Issue number2
StatePublished - Feb 2007
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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