Caspofungin at catheter lock concentrations eradicates mature biofilms of Candida lusitaniae and Candida guilliermondii

Maria Simitsopoulou, Daniela Kyrpitzi, Aristea Velegraki, Thomas J. Walsh, Emmanuel Roilides

Research output: Contribution to journalArticle

Abstract

The antibiofilm activities of caspofungin, anidulafungin, micafungin, and liposomal amphotericin B were studied against Candida lusitaniae, Candida guilliermondii, and a Candida albicans control strain. While anidulafungin and micafungin (0.007 to 2,048 mg/liter) showed reduced activity against biofilms of both test species, caspofungin displayed concentration-dependent antibiofilm activity, reaching complete and persistent eradication at concentrations achievable during lock therapy (512 to 2,048 mg/liter, P<0.05). Although liposomal amphotericin B strongly inhibited mature biofilms, it possessed lower antibiofilm activity than caspofungin (P<0.05).

Original languageEnglish (US)
Pages (from-to)4953-4956
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number8
DOIs
StatePublished - Aug 2014

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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