Cases of aphasia or neglect due to Creutzfeldt-Jakob disease

Argye Elizabeth Hillis; Ola Selnes

doi:10.1080/026870399401849

Cases of aphasia or neglect due to Creutzfeldt-Jakob disease

Research output: Contribution to journal › Article › peer-review

Abstract

Two patients with CJD whose deficits are attributable to damage to selective cognitive mechanisms are described. One patient presented with 'pure word deafness' with severe anemia and progressed to Global aphasia. EEG and SPECT showed left cortical abnormalities. The other presented with progressive left neglect and digressive speech with meager interpretive content, but never developed aphasia. EEG showed right cortical abnormalities. These cases provide evidence that CJD can begin focally and unilaterally. Several cases of progressive aphasia due to CJD have been described, but this may be the first reported case of progressive right hemisphere dysfunction due to CJD.

Original language	English (US)
Pages (from-to)	743-754
Number of pages	12
Journal	Aphasiology
Volume	13
Issue number	9-11
DOIs	https://doi.org/10.1080/026870399401849
State	Published - Sep 1999

ASJC Scopus subject areas

Otorhinolaryngology
Language and Linguistics
Developmental and Educational Psychology
Linguistics and Language
Neurology
Clinical Neurology
LPN and LVN

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10.1080/026870399401849

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title = "Cases of aphasia or neglect due to Creutzfeldt-Jakob disease",

abstract = "Two patients with CJD whose deficits are attributable to damage to selective cognitive mechanisms are described. One patient presented with 'pure word deafness' with severe anemia and progressed to Global aphasia. EEG and SPECT showed left cortical abnormalities. The other presented with progressive left neglect and digressive speech with meager interpretive content, but never developed aphasia. EEG showed right cortical abnormalities. These cases provide evidence that CJD can begin focally and unilaterally. Several cases of progressive aphasia due to CJD have been described, but this may be the first reported case of progressive right hemisphere dysfunction due to CJD.",

author = "Hillis, {Argye Elizabeth} and Ola Selnes",

note = "Funding Information: The authors are grateful to A HG and RG N and ther faimiilsefor partcpiatiing in this study and to Dr Rihcard Johnson and Dr DouglaKserr for refreing rAHG and RG N to us. We aso lappreitceathe hepfull comments of Kevin Kernas on an erlieadrraft of this paper. The research here was supported in part by NIH grant NS 34073 to Harvard Universit. y",

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language = "English (US)",

volume = "13",

pages = "743--754",

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AU - Hillis, Argye Elizabeth

AU - Selnes, Ola

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PY - 1999/9

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N2 - Two patients with CJD whose deficits are attributable to damage to selective cognitive mechanisms are described. One patient presented with 'pure word deafness' with severe anemia and progressed to Global aphasia. EEG and SPECT showed left cortical abnormalities. The other presented with progressive left neglect and digressive speech with meager interpretive content, but never developed aphasia. EEG showed right cortical abnormalities. These cases provide evidence that CJD can begin focally and unilaterally. Several cases of progressive aphasia due to CJD have been described, but this may be the first reported case of progressive right hemisphere dysfunction due to CJD.

AB - Two patients with CJD whose deficits are attributable to damage to selective cognitive mechanisms are described. One patient presented with 'pure word deafness' with severe anemia and progressed to Global aphasia. EEG and SPECT showed left cortical abnormalities. The other presented with progressive left neglect and digressive speech with meager interpretive content, but never developed aphasia. EEG showed right cortical abnormalities. These cases provide evidence that CJD can begin focally and unilaterally. Several cases of progressive aphasia due to CJD have been described, but this may be the first reported case of progressive right hemisphere dysfunction due to CJD.

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Cases of aphasia or neglect due to Creutzfeldt-Jakob disease

Abstract

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