Caseous calcification of the mitral annulus mimicking circumflex coronary artery aneurysm

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Imaging description Caseous, or liquefactive, calcification of the mitral annulus is a rare variant of mitral annular calcification. In caseous mitral annular calcification, a smooth, ovoid mass is found within the mitral annulus with rim calcification and a homogenous, moderately hyperattenuating center on computed tomography (CT) (Figure 39.1). The liquefactive center of the lesion is not as densely hyperattenuating as vascular or osseous calcifications. In some cases, the center of the lesion may contain low-attenuation components (Figure 39.2). These masses are commonly located in the inferior or lateral aspect of the left atrioventricular groove and may displace mitral valve leaflets from mass effect. In some cases, multiple masses or continuous calcification around the entire mitral valve annulus may be seen (Figure 39.3). Caseous calcification may be initially discovered at echocardiography, where they appear as a rounded echogenic mass with central hypoechogenicity due to a central core of liquefactive necrosis. At pathology, the center of these lesions is composed of a toothpaste-like material that represents a mix of calcium, fatty acids, and cholesterol. Importance Rounded masses of caseous mitral annular calcification can be incorrectly diagnosed as circumflex coronary artery aneurysms, given their similar location and attenuation on contrast-enhanced CT (Figure 39.1). This could lead to additional inappropriate diagnostic tests, such as cardiac catheterization, or surgery. Caseous mitral calcification is a benign condition; however, rare complications due to ulceration resulting in distal embolization and/or endocarditis have been reported. Caseous calcifications may also be associated with mitral valve stenosis or regurgitation due to mass effect. Typical clinical scenario Caseous mitral annular calcification is an uncommon condition, with a prevalence of <0.1% in large echocardiographic studies. Among patients with mitral annular calcification, caseous degeneration is reported in <1% of cases. Caseous mitral calcification is typically an incidental finding on CT, MR, or echocardiographic exams performed for other reasons. Occasionally, patients may be referred to cardiac CT or MRI for definitive evaluation if the diagnosis is unclear on echocardiography.

Original languageEnglish (US)
Title of host publicationPearls and Pitfalls in Cardiovascular Imaging: Pseudolesions, Artifacts and Other Difficult Diagnoses
PublisherCambridge University Press
Pages124-126
Number of pages3
ISBN (Print)9781139152228, 9781107023727
DOIs
StatePublished - Jan 1 2015

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Coronary Aneurysm
Coronary Vessels
Tomography
Mitral Valve
Echocardiography
Toothpastes
Incidental Findings
Mitral Valve Stenosis
Mitral Valve Insufficiency
Cardiac Catheterization
Endocarditis
Routine Diagnostic Tests
Thoracic Surgery
Blood Vessels
Necrosis
Fatty Acids
Cholesterol
Magnetic Resonance Imaging
Pathology
Calcium

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Zimmerman, S. (2015). Caseous calcification of the mitral annulus mimicking circumflex coronary artery aneurysm. In Pearls and Pitfalls in Cardiovascular Imaging: Pseudolesions, Artifacts and Other Difficult Diagnoses (pp. 124-126). Cambridge University Press. https://doi.org/10.1017/CBO9781139152228.040

Caseous calcification of the mitral annulus mimicking circumflex coronary artery aneurysm. / Zimmerman, Stefan.

Pearls and Pitfalls in Cardiovascular Imaging: Pseudolesions, Artifacts and Other Difficult Diagnoses. Cambridge University Press, 2015. p. 124-126.

Research output: Chapter in Book/Report/Conference proceedingChapter

Zimmerman, S 2015, Caseous calcification of the mitral annulus mimicking circumflex coronary artery aneurysm. in Pearls and Pitfalls in Cardiovascular Imaging: Pseudolesions, Artifacts and Other Difficult Diagnoses. Cambridge University Press, pp. 124-126. https://doi.org/10.1017/CBO9781139152228.040
Zimmerman S. Caseous calcification of the mitral annulus mimicking circumflex coronary artery aneurysm. In Pearls and Pitfalls in Cardiovascular Imaging: Pseudolesions, Artifacts and Other Difficult Diagnoses. Cambridge University Press. 2015. p. 124-126 https://doi.org/10.1017/CBO9781139152228.040
Zimmerman, Stefan. / Caseous calcification of the mitral annulus mimicking circumflex coronary artery aneurysm. Pearls and Pitfalls in Cardiovascular Imaging: Pseudolesions, Artifacts and Other Difficult Diagnoses. Cambridge University Press, 2015. pp. 124-126
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abstract = "Imaging description Caseous, or liquefactive, calcification of the mitral annulus is a rare variant of mitral annular calcification. In caseous mitral annular calcification, a smooth, ovoid mass is found within the mitral annulus with rim calcification and a homogenous, moderately hyperattenuating center on computed tomography (CT) (Figure 39.1). The liquefactive center of the lesion is not as densely hyperattenuating as vascular or osseous calcifications. In some cases, the center of the lesion may contain low-attenuation components (Figure 39.2). These masses are commonly located in the inferior or lateral aspect of the left atrioventricular groove and may displace mitral valve leaflets from mass effect. In some cases, multiple masses or continuous calcification around the entire mitral valve annulus may be seen (Figure 39.3). Caseous calcification may be initially discovered at echocardiography, where they appear as a rounded echogenic mass with central hypoechogenicity due to a central core of liquefactive necrosis. At pathology, the center of these lesions is composed of a toothpaste-like material that represents a mix of calcium, fatty acids, and cholesterol. Importance Rounded masses of caseous mitral annular calcification can be incorrectly diagnosed as circumflex coronary artery aneurysms, given their similar location and attenuation on contrast-enhanced CT (Figure 39.1). This could lead to additional inappropriate diagnostic tests, such as cardiac catheterization, or surgery. Caseous mitral calcification is a benign condition; however, rare complications due to ulceration resulting in distal embolization and/or endocarditis have been reported. Caseous calcifications may also be associated with mitral valve stenosis or regurgitation due to mass effect. Typical clinical scenario Caseous mitral annular calcification is an uncommon condition, with a prevalence of <0.1{\%} in large echocardiographic studies. Among patients with mitral annular calcification, caseous degeneration is reported in <1{\%} of cases. Caseous mitral calcification is typically an incidental finding on CT, MR, or echocardiographic exams performed for other reasons. Occasionally, patients may be referred to cardiac CT or MRI for definitive evaluation if the diagnosis is unclear on echocardiography.",
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