Casein production by human breast cancer

M. E. Monaco, D. A. Bronzert, D. C. Tormey, P. Waalkes, M. E. Lippman

Research output: Contribution to journalArticle

Abstract

Casein was measured in the sera of breast cancer patients, in breast cancers and in breast cancer cells in long term tissue culture using a sensitive and specific radioimmunoassay. Level % breast cancer sera showed control values. Eight of 47 (17%) of the tumor samples tested were positive for casein, the highest level representing 0.003% of the soluble protein. When 7 human breast cancer cell lines were assayed for casein, the results were uniformly negative even under conditions of stimulation by lactogenic hormones (placental lactogen, insulin, dexamethasone, estradiol, progesterone). In addition, direct immunoprecipitation of labeled cellular protein supported the negative result of the radioimmunoassay. Thus it appears that casein production is normally activated only in the fully developed lactating breast stimulated by a number of hormones. Therefore one might not expect casein production under conditions of malignant growth.

Original languageEnglish (US)
Pages (from-to)749-754
Number of pages6
JournalCancer Research
Volume37
Issue number3
StatePublished - 1977
Externally publishedYes

Fingerprint

Caseins
Breast Neoplasms
Radioimmunoassay
Placental Lactogen
Serum
Immunoprecipitation
Dexamethasone
Progesterone
Estradiol
Proteins
Breast
Hormones
Insulin
Cell Line
Growth
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Monaco, M. E., Bronzert, D. A., Tormey, D. C., Waalkes, P., & Lippman, M. E. (1977). Casein production by human breast cancer. Cancer Research, 37(3), 749-754.

Casein production by human breast cancer. / Monaco, M. E.; Bronzert, D. A.; Tormey, D. C.; Waalkes, P.; Lippman, M. E.

In: Cancer Research, Vol. 37, No. 3, 1977, p. 749-754.

Research output: Contribution to journalArticle

Monaco, ME, Bronzert, DA, Tormey, DC, Waalkes, P & Lippman, ME 1977, 'Casein production by human breast cancer', Cancer Research, vol. 37, no. 3, pp. 749-754.
Monaco ME, Bronzert DA, Tormey DC, Waalkes P, Lippman ME. Casein production by human breast cancer. Cancer Research. 1977;37(3):749-754.
Monaco, M. E. ; Bronzert, D. A. ; Tormey, D. C. ; Waalkes, P. ; Lippman, M. E. / Casein production by human breast cancer. In: Cancer Research. 1977 ; Vol. 37, No. 3. pp. 749-754.
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