Case definitions, diagnostic algorithms, and priorities in encephalitis: Consensus statement of the international encephalitis consortium

Arun Venkatesan, A. R. Tunkel, K. C. Bloch, A. S. Lauring, J. Sejvar, A. Bitnun, J. P. Stahl, A. Mailles, M. Drebot, C. E. Rupprecht, J. Yoder, J. R. Cope, M. R. Wilson, R. J. Whitley, J. Sullivan, J. Granerod, C. Jones, K. Eastwood, K. N. Ward, D. N. DurrheimM. V. Solbrig, L. Guo-Dong, C. A. Glaser, Heather Sheriff, David Brown, Eileen Farnon, Sharon Messenger, Beverley Paterson, Ariane Soldatos, Sharon Roy, Govinda Visvesvara, Michael Beach, Roger Nasci, Carol Pertowski, Scott Schmid, Lisa Rascoe, Joel Montgomery, Suxiang Tong, Robert Breiman, Richard Franka, Matt Keuhnert, Fred Angulo, James Cherry

Research output: Contribution to journalArticle

Abstract

Background. Encephalitis continues to result in substantial morbidity and mortality worldwide. Advances in diagnosis and management have been limited, in part, by a lack of consensus on case definitions, standardized diagnostic approaches, and priorities for research.Methods. In March 2012, the International Encephalitis Consortium, a committee begun in 2010 with members worldwide, held a meeting in Atlanta to discuss recent advances in encephalitis and to set priorities for future study.Results. We present a consensus document that proposes a standardized case definition and diagnostic guidelines for evaluation of adults and children with suspected encephalitis. In addition, areas of research priority, including host genetics and selected emerging infections, are discussed.Conclusions. We anticipate that this document, representing a synthesis of our discussions and supported by literature, will serve as a practical aid to clinicians evaluating patients with suspected encephalitis and will identify key areas and approaches to advance our knowledge of encephalitis.

Original languageEnglish (US)
Pages (from-to)1114-1128
Number of pages15
JournalClinical Infectious Diseases
Volume57
Issue number8
DOIs
StatePublished - Oct 15 2013

Fingerprint

Encephalitis
Research
Guidelines
Morbidity
Mortality
Infection

Keywords

  • autoimmune
  • encephalitis
  • guidelines
  • host genetics
  • viral

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Case definitions, diagnostic algorithms, and priorities in encephalitis : Consensus statement of the international encephalitis consortium. / Venkatesan, Arun; Tunkel, A. R.; Bloch, K. C.; Lauring, A. S.; Sejvar, J.; Bitnun, A.; Stahl, J. P.; Mailles, A.; Drebot, M.; Rupprecht, C. E.; Yoder, J.; Cope, J. R.; Wilson, M. R.; Whitley, R. J.; Sullivan, J.; Granerod, J.; Jones, C.; Eastwood, K.; Ward, K. N.; Durrheim, D. N.; Solbrig, M. V.; Guo-Dong, L.; Glaser, C. A.; Sheriff, Heather; Brown, David; Farnon, Eileen; Messenger, Sharon; Paterson, Beverley; Soldatos, Ariane; Roy, Sharon; Visvesvara, Govinda; Beach, Michael; Nasci, Roger; Pertowski, Carol; Schmid, Scott; Rascoe, Lisa; Montgomery, Joel; Tong, Suxiang; Breiman, Robert; Franka, Richard; Keuhnert, Matt; Angulo, Fred; Cherry, James.

In: Clinical Infectious Diseases, Vol. 57, No. 8, 15.10.2013, p. 1114-1128.

Research output: Contribution to journalArticle

Venkatesan, A, Tunkel, AR, Bloch, KC, Lauring, AS, Sejvar, J, Bitnun, A, Stahl, JP, Mailles, A, Drebot, M, Rupprecht, CE, Yoder, J, Cope, JR, Wilson, MR, Whitley, RJ, Sullivan, J, Granerod, J, Jones, C, Eastwood, K, Ward, KN, Durrheim, DN, Solbrig, MV, Guo-Dong, L, Glaser, CA, Sheriff, H, Brown, D, Farnon, E, Messenger, S, Paterson, B, Soldatos, A, Roy, S, Visvesvara, G, Beach, M, Nasci, R, Pertowski, C, Schmid, S, Rascoe, L, Montgomery, J, Tong, S, Breiman, R, Franka, R, Keuhnert, M, Angulo, F & Cherry, J 2013, 'Case definitions, diagnostic algorithms, and priorities in encephalitis: Consensus statement of the international encephalitis consortium', Clinical Infectious Diseases, vol. 57, no. 8, pp. 1114-1128. https://doi.org/10.1093/cid/cit458
Venkatesan, Arun ; Tunkel, A. R. ; Bloch, K. C. ; Lauring, A. S. ; Sejvar, J. ; Bitnun, A. ; Stahl, J. P. ; Mailles, A. ; Drebot, M. ; Rupprecht, C. E. ; Yoder, J. ; Cope, J. R. ; Wilson, M. R. ; Whitley, R. J. ; Sullivan, J. ; Granerod, J. ; Jones, C. ; Eastwood, K. ; Ward, K. N. ; Durrheim, D. N. ; Solbrig, M. V. ; Guo-Dong, L. ; Glaser, C. A. ; Sheriff, Heather ; Brown, David ; Farnon, Eileen ; Messenger, Sharon ; Paterson, Beverley ; Soldatos, Ariane ; Roy, Sharon ; Visvesvara, Govinda ; Beach, Michael ; Nasci, Roger ; Pertowski, Carol ; Schmid, Scott ; Rascoe, Lisa ; Montgomery, Joel ; Tong, Suxiang ; Breiman, Robert ; Franka, Richard ; Keuhnert, Matt ; Angulo, Fred ; Cherry, James. / Case definitions, diagnostic algorithms, and priorities in encephalitis : Consensus statement of the international encephalitis consortium. In: Clinical Infectious Diseases. 2013 ; Vol. 57, No. 8. pp. 1114-1128.
@article{9c146258e4f941dbb42daf60f906cc6f,
title = "Case definitions, diagnostic algorithms, and priorities in encephalitis: Consensus statement of the international encephalitis consortium",
abstract = "Background. Encephalitis continues to result in substantial morbidity and mortality worldwide. Advances in diagnosis and management have been limited, in part, by a lack of consensus on case definitions, standardized diagnostic approaches, and priorities for research.Methods. In March 2012, the International Encephalitis Consortium, a committee begun in 2010 with members worldwide, held a meeting in Atlanta to discuss recent advances in encephalitis and to set priorities for future study.Results. We present a consensus document that proposes a standardized case definition and diagnostic guidelines for evaluation of adults and children with suspected encephalitis. In addition, areas of research priority, including host genetics and selected emerging infections, are discussed.Conclusions. We anticipate that this document, representing a synthesis of our discussions and supported by literature, will serve as a practical aid to clinicians evaluating patients with suspected encephalitis and will identify key areas and approaches to advance our knowledge of encephalitis.",
keywords = "autoimmune, encephalitis, guidelines, host genetics, viral",
author = "Arun Venkatesan and Tunkel, {A. R.} and Bloch, {K. C.} and Lauring, {A. S.} and J. Sejvar and A. Bitnun and Stahl, {J. P.} and A. Mailles and M. Drebot and Rupprecht, {C. E.} and J. Yoder and Cope, {J. R.} and Wilson, {M. R.} and Whitley, {R. J.} and J. Sullivan and J. Granerod and C. Jones and K. Eastwood and Ward, {K. N.} and Durrheim, {D. N.} and Solbrig, {M. V.} and L. Guo-Dong and Glaser, {C. A.} and Heather Sheriff and David Brown and Eileen Farnon and Sharon Messenger and Beverley Paterson and Ariane Soldatos and Sharon Roy and Govinda Visvesvara and Michael Beach and Roger Nasci and Carol Pertowski and Scott Schmid and Lisa Rascoe and Joel Montgomery and Suxiang Tong and Robert Breiman and Richard Franka and Matt Keuhnert and Fred Angulo and James Cherry",
year = "2013",
month = "10",
day = "15",
doi = "10.1093/cid/cit458",
language = "English (US)",
volume = "57",
pages = "1114--1128",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Case definitions, diagnostic algorithms, and priorities in encephalitis

T2 - Consensus statement of the international encephalitis consortium

AU - Venkatesan, Arun

AU - Tunkel, A. R.

AU - Bloch, K. C.

AU - Lauring, A. S.

AU - Sejvar, J.

AU - Bitnun, A.

AU - Stahl, J. P.

AU - Mailles, A.

AU - Drebot, M.

AU - Rupprecht, C. E.

AU - Yoder, J.

AU - Cope, J. R.

AU - Wilson, M. R.

AU - Whitley, R. J.

AU - Sullivan, J.

AU - Granerod, J.

AU - Jones, C.

AU - Eastwood, K.

AU - Ward, K. N.

AU - Durrheim, D. N.

AU - Solbrig, M. V.

AU - Guo-Dong, L.

AU - Glaser, C. A.

AU - Sheriff, Heather

AU - Brown, David

AU - Farnon, Eileen

AU - Messenger, Sharon

AU - Paterson, Beverley

AU - Soldatos, Ariane

AU - Roy, Sharon

AU - Visvesvara, Govinda

AU - Beach, Michael

AU - Nasci, Roger

AU - Pertowski, Carol

AU - Schmid, Scott

AU - Rascoe, Lisa

AU - Montgomery, Joel

AU - Tong, Suxiang

AU - Breiman, Robert

AU - Franka, Richard

AU - Keuhnert, Matt

AU - Angulo, Fred

AU - Cherry, James

PY - 2013/10/15

Y1 - 2013/10/15

N2 - Background. Encephalitis continues to result in substantial morbidity and mortality worldwide. Advances in diagnosis and management have been limited, in part, by a lack of consensus on case definitions, standardized diagnostic approaches, and priorities for research.Methods. In March 2012, the International Encephalitis Consortium, a committee begun in 2010 with members worldwide, held a meeting in Atlanta to discuss recent advances in encephalitis and to set priorities for future study.Results. We present a consensus document that proposes a standardized case definition and diagnostic guidelines for evaluation of adults and children with suspected encephalitis. In addition, areas of research priority, including host genetics and selected emerging infections, are discussed.Conclusions. We anticipate that this document, representing a synthesis of our discussions and supported by literature, will serve as a practical aid to clinicians evaluating patients with suspected encephalitis and will identify key areas and approaches to advance our knowledge of encephalitis.

AB - Background. Encephalitis continues to result in substantial morbidity and mortality worldwide. Advances in diagnosis and management have been limited, in part, by a lack of consensus on case definitions, standardized diagnostic approaches, and priorities for research.Methods. In March 2012, the International Encephalitis Consortium, a committee begun in 2010 with members worldwide, held a meeting in Atlanta to discuss recent advances in encephalitis and to set priorities for future study.Results. We present a consensus document that proposes a standardized case definition and diagnostic guidelines for evaluation of adults and children with suspected encephalitis. In addition, areas of research priority, including host genetics and selected emerging infections, are discussed.Conclusions. We anticipate that this document, representing a synthesis of our discussions and supported by literature, will serve as a practical aid to clinicians evaluating patients with suspected encephalitis and will identify key areas and approaches to advance our knowledge of encephalitis.

KW - autoimmune

KW - encephalitis

KW - guidelines

KW - host genetics

KW - viral

UR - http://www.scopus.com/inward/record.url?scp=84884920102&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884920102&partnerID=8YFLogxK

U2 - 10.1093/cid/cit458

DO - 10.1093/cid/cit458

M3 - Article

C2 - 23861361

AN - SCOPUS:84884920102

VL - 57

SP - 1114

EP - 1128

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 8

ER -