Case definitions, diagnostic algorithms, and priorities in encephalitis: Consensus statement of the international encephalitis consortium

A. Venkatesan, A. R. Tunkel, K. C. Bloch, A. S. Lauring, J. Sejvar, A. Bitnun, J. P. Stahl, A. Mailles, M. Drebot, C. E. Rupprecht, J. Yoder, J. R. Cope, M. R. Wilson, R. J. Whitley, J. Sullivan, J. Granerod, C. Jones, K. Eastwood, K. N. Ward, D. N. DurrheimM. V. Solbrig, L. Guo-Dong, C. A. Glaser, Heather Sheriff, David Brown, Eileen Farnon, Sharon Messenger, Beverley Paterson, Ariane Soldatos, Sharon Roy, Govinda Visvesvara, Michael Beach, Roger Nasci, Carol Pertowski, Scott Schmid, Lisa Rascoe, Joel Montgomery, Suxiang Tong, Robert Breiman, Richard Franka, Matt Keuhnert, Fred Angulo, James Cherry

Research output: Contribution to journalArticle

Abstract

Background. Encephalitis continues to result in substantial morbidity and mortality worldwide. Advances in diagnosis and management have been limited, in part, by a lack of consensus on case definitions, standardized diagnostic approaches, and priorities for research.Methods. In March 2012, the International Encephalitis Consortium, a committee begun in 2010 with members worldwide, held a meeting in Atlanta to discuss recent advances in encephalitis and to set priorities for future study.Results. We present a consensus document that proposes a standardized case definition and diagnostic guidelines for evaluation of adults and children with suspected encephalitis. In addition, areas of research priority, including host genetics and selected emerging infections, are discussed.Conclusions. We anticipate that this document, representing a synthesis of our discussions and supported by literature, will serve as a practical aid to clinicians evaluating patients with suspected encephalitis and will identify key areas and approaches to advance our knowledge of encephalitis.

Original languageEnglish (US)
Pages (from-to)1114-1128
Number of pages15
JournalClinical Infectious Diseases
Volume57
Issue number8
DOIs
StatePublished - Oct 15 2013

Keywords

  • autoimmune
  • encephalitis
  • guidelines
  • host genetics
  • viral

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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