Case-control study of endemic diarrheal disease in thai children

Peter Echeverria, David N. Taylor, Udom Lexsomboon, Manoon Bhaibulaya, Neil R. Blacklow, Kazumichi Tamura, Riichi Sakazaki

Research output: Contribution to journalArticlepeer-review


In a year-long, case-control study of endemic diarrheal disease among 1230 Thai children less than five years of age, rotavirus was detected in 20%, Campylobacter in 13%, Shigella in 13%, Salmonella in 12%, and enterotoxigenic Escherichia coli (ETEC) in 9%. The differences in detection of enteric pathogens between patients and controls was significant for rotavirus (P<.001), Shigella (P<.001), ETEC that produced heat-labile and heat-stable toxins (LT and ST; P =.005), and ST only (P <.001). C. jejuni was most significantly associated with diarrhea in children less than 12 years old (P =.037) and Salmonella in children less than three months of age (P =.003). Enteropathogenic E. coli (EPEC) that adhered in a localized pattern to HeLa cells was isolated from 7% of patients and 3% of controls less than six months of age. Only 50% of these E. coli strains were of EPEC serotypes. Enteroinvasive E. coli was isolated from 7% of patients more than two years of age, and new serotypes were identified.

Original languageEnglish (US)
Pages (from-to)543-548
Number of pages6
JournalJournal of Infectious Diseases
Issue number3
StatePublished - Mar 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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