Case-cohort analysis of case-coverage studies of vaccine effectiveness

Lawrence H. Moulton; Mark C. Wolff; George Brenneman; Mathuram Santosham

doi:10.1093/oxfordjournals.aje.a117730

Case-cohort analysis of case-coverage studies of vaccine effectiveness

Lawrence H. Moulton, Mark C. Wolff, George Brenneman, Mathuram Santosham

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Evaluation of vaccine field effectiveness may be performed by combining surveillance data on incident cases with an immunization coverage survey. Although many methods have been used for the analysis of studies of similar design, they are not always desirable or optimal. The authors discuss these approaches and propose use of a case-cohort analysis for such a study design when appropriate. The case-cohort analytic approach is illustrated with data from studies of a vaccine for Haemophilus influenzae type b (Hib) disease in children living on a southwestern Native American reservation during 1988-1993.

Original language	English (US)
Pages (from-to)	1000-1006
Number of pages	7
Journal	American journal of epidemiology
Volume	142
Issue number	9
DOIs	https://doi.org/10.1093/oxfordjournals.aje.a117730
State	Published - Nov 1 1995

Keywords

Biometry
Epidemiologic methods
Follow-up studies
Research design
Statistics
Vaccination

ASJC Scopus subject areas

Epidemiology

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10.1093/oxfordjournals.aje.a117730

Cite this

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abstract = "Evaluation of vaccine field effectiveness may be performed by combining surveillance data on incident cases with an immunization coverage survey. Although many methods have been used for the analysis of studies of similar design, they are not always desirable or optimal. The authors discuss these approaches and propose use of a case-cohort analysis for such a study design when appropriate. The case-cohort analytic approach is illustrated with data from studies of a vaccine for Haemophilus influenzae type b (Hib) disease in children living on a southwestern Native American reservation during 1988-1993.",

keywords = "Biometry, Epidemiologic methods, Follow-up studies, Research design, Statistics, Vaccination",

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AU - Wolff, Mark C.

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AU - Santosham, Mathuram

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N2 - Evaluation of vaccine field effectiveness may be performed by combining surveillance data on incident cases with an immunization coverage survey. Although many methods have been used for the analysis of studies of similar design, they are not always desirable or optimal. The authors discuss these approaches and propose use of a case-cohort analysis for such a study design when appropriate. The case-cohort analytic approach is illustrated with data from studies of a vaccine for Haemophilus influenzae type b (Hib) disease in children living on a southwestern Native American reservation during 1988-1993.

AB - Evaluation of vaccine field effectiveness may be performed by combining surveillance data on incident cases with an immunization coverage survey. Although many methods have been used for the analysis of studies of similar design, they are not always desirable or optimal. The authors discuss these approaches and propose use of a case-cohort analysis for such a study design when appropriate. The case-cohort analytic approach is illustrated with data from studies of a vaccine for Haemophilus influenzae type b (Hib) disease in children living on a southwestern Native American reservation during 1988-1993.

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KW - Follow-up studies

KW - Research design

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Case-cohort analysis of case-coverage studies of vaccine effectiveness

Abstract

Keywords

ASJC Scopus subject areas

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