Case-ascertained study of household transmission of seasonal influenza - South Africa, 2013

Preetha Iyengar, Claire von Mollendorf, Stefano Tempia, Alexandra Moerdyk, Ziyaad Valley-Omar, Orienka Hellferscee, Neil Martinson, Meera Chhagan, Meredith McMorrow, Manoj Gambhir, Simon Cauchemez, Ebrahim Variava, Katlego Masonoke, Adam L. Cohen, Cheryl Cohen

Research output: Contribution to journalArticle

Abstract

Objectives: The household is important in influenza transmission due to intensity of contact. Previous studies reported secondary attack rates (SAR) of 4-10% for laboratory-confirmed influenza in the household. Few have been conducted in middle-income countries. Methods: We performed a case-ascertained household transmission study during May-October 2013. Index cases were patients with influenza-like-illness (cough and self-reported or measured fever (≥38 °C)) with onset in the last 3 days and no sick household contacts, at clinics in South Africa. Household contacts of index cases with laboratory-confirmed influenza were followed for 12 days. Results: Thirty index cases in 30 households and 107/110 (97%) eligible household contacts were enrolled. Assuming those not enrolled were influenza negative, 21/110 household contacts had laboratory-confirmed influenza (SAR 19%); the mean serial interval was 2.1 days (SD = 0.35, range 2-3 days). Most (62/82; 76%) household contacts who completed the risk factor questionnaire never avoided contact and 43/82 (52%) continued to share a bed with the index case after illness onset. Conclusion: SAR for laboratory-confirmed influenza in South Africa was higher than previously reported SARs. Household contacts did not report changing behaviors to prevent transmission. These results can be used to understand and predict influenza transmission in similar middle-income settings.

Original languageEnglish (US)
Pages (from-to)578-586
Number of pages9
JournalJournal of Infection
Volume71
Issue number5
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

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South Africa
Human Influenza
Sick Leave
Cough
Fever

Keywords

  • Household transmission
  • Influenza
  • Secondary infection risk
  • Serial interval
  • South Africa

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Iyengar, P., von Mollendorf, C., Tempia, S., Moerdyk, A., Valley-Omar, Z., Hellferscee, O., ... Cohen, C. (2015). Case-ascertained study of household transmission of seasonal influenza - South Africa, 2013. Journal of Infection, 71(5), 578-586. https://doi.org/10.1016/j.jinf.2015.09.001

Case-ascertained study of household transmission of seasonal influenza - South Africa, 2013. / Iyengar, Preetha; von Mollendorf, Claire; Tempia, Stefano; Moerdyk, Alexandra; Valley-Omar, Ziyaad; Hellferscee, Orienka; Martinson, Neil; Chhagan, Meera; McMorrow, Meredith; Gambhir, Manoj; Cauchemez, Simon; Variava, Ebrahim; Masonoke, Katlego; Cohen, Adam L.; Cohen, Cheryl.

In: Journal of Infection, Vol. 71, No. 5, 01.11.2015, p. 578-586.

Research output: Contribution to journalArticle

Iyengar, P, von Mollendorf, C, Tempia, S, Moerdyk, A, Valley-Omar, Z, Hellferscee, O, Martinson, N, Chhagan, M, McMorrow, M, Gambhir, M, Cauchemez, S, Variava, E, Masonoke, K, Cohen, AL & Cohen, C 2015, 'Case-ascertained study of household transmission of seasonal influenza - South Africa, 2013', Journal of Infection, vol. 71, no. 5, pp. 578-586. https://doi.org/10.1016/j.jinf.2015.09.001
Iyengar P, von Mollendorf C, Tempia S, Moerdyk A, Valley-Omar Z, Hellferscee O et al. Case-ascertained study of household transmission of seasonal influenza - South Africa, 2013. Journal of Infection. 2015 Nov 1;71(5):578-586. https://doi.org/10.1016/j.jinf.2015.09.001
Iyengar, Preetha ; von Mollendorf, Claire ; Tempia, Stefano ; Moerdyk, Alexandra ; Valley-Omar, Ziyaad ; Hellferscee, Orienka ; Martinson, Neil ; Chhagan, Meera ; McMorrow, Meredith ; Gambhir, Manoj ; Cauchemez, Simon ; Variava, Ebrahim ; Masonoke, Katlego ; Cohen, Adam L. ; Cohen, Cheryl. / Case-ascertained study of household transmission of seasonal influenza - South Africa, 2013. In: Journal of Infection. 2015 ; Vol. 71, No. 5. pp. 578-586.
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AU - Tempia, Stefano

AU - Moerdyk, Alexandra

AU - Valley-Omar, Ziyaad

AU - Hellferscee, Orienka

AU - Martinson, Neil

AU - Chhagan, Meera

AU - McMorrow, Meredith

AU - Gambhir, Manoj

AU - Cauchemez, Simon

AU - Variava, Ebrahim

AU - Masonoke, Katlego

AU - Cohen, Adam L.

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