Cartilage Tissue Engineering

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter provides an introduction to tissue engineering for cartilage repair. Tissue engineering scaffolds are designed to provide a 3D environment to support and direct cellular processes in their migration, proliferation, and differentiation toward functional tissue. The selection of bioscaffolds for cartilage engineering requires excellent mechanical properties to support cellular functions, biocompatibility, capability of waste and nutrient transport, and sufficient structural integrity for joint reconstruction. Both natural and synthetic materials are applied as cartilage tissue engineering scaffolds in a variety of forms, including fibrous structures, porous sponges, woven or nonwoven meshes, and hydrogels. Biological factors are commonly applied to guide cellular differentiation, migration, adhesion, and gene expression. These factors include soluble biochemical signals, transfection of gene vectors, and cell-cell interactions. Soluble signaling molecules are used to instruct cells to proliferate, differentiate, and generate cartilage matrix during cartilage tissue reconstruction. The signaling molecules of growth factors are investigated intensively, especially TGFβ superfamily, several bone morphogenetic protein (BMPs), insulin-like growth factor (IGF)-1, fibroblast growth factors (FGFs), and epidermal growth factor (EGF). Gene therapy techniques are developed to deliver therapeutic genes encoding necessary gene products to cells at the site of cartilage injury to synthesize biological factors of interest for sustained local expression. Bioreactors are developed to provide adequate mass transfer and mechanical stimulation in order to enhance the biochemical and mechanical properties of engineered cartilage tissues.

Original languageEnglish (US)
Title of host publicationPrinciples of Regenerative Medicine
PublisherElsevier Inc.
Pages981-995
Number of pages15
ISBN (Print)9780123814227
DOIs
StatePublished - 2011

Fingerprint

Cartilage
Tissue Engineering
Tissue engineering
Tissue Scaffolds
Biological Factors
Tissue
Genes
Fibroblast Growth Factor 1
Gene therapy
Mechanical properties
Bone Morphogenetic Proteins
Molecules
Hydrogels
Gene encoding
Porifera
Bioreactors
Structural integrity
Somatomedins
Biocompatibility
Epidermal Growth Factor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Guo, Q., & Elisseeff, J. H. (2011). Cartilage Tissue Engineering. In Principles of Regenerative Medicine (pp. 981-995). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-381422-7.10053-7

Cartilage Tissue Engineering. / Guo, Qiongyu; Elisseeff, Jennifer Hartt.

Principles of Regenerative Medicine. Elsevier Inc., 2011. p. 981-995.

Research output: Chapter in Book/Report/Conference proceedingChapter

Guo, Q & Elisseeff, JH 2011, Cartilage Tissue Engineering. in Principles of Regenerative Medicine. Elsevier Inc., pp. 981-995. https://doi.org/10.1016/B978-0-12-381422-7.10053-7
Guo Q, Elisseeff JH. Cartilage Tissue Engineering. In Principles of Regenerative Medicine. Elsevier Inc. 2011. p. 981-995 https://doi.org/10.1016/B978-0-12-381422-7.10053-7
Guo, Qiongyu ; Elisseeff, Jennifer Hartt. / Cartilage Tissue Engineering. Principles of Regenerative Medicine. Elsevier Inc., 2011. pp. 981-995
@inbook{e3680d4cd4a84c4ab2ef81106365b493,
title = "Cartilage Tissue Engineering",
abstract = "This chapter provides an introduction to tissue engineering for cartilage repair. Tissue engineering scaffolds are designed to provide a 3D environment to support and direct cellular processes in their migration, proliferation, and differentiation toward functional tissue. The selection of bioscaffolds for cartilage engineering requires excellent mechanical properties to support cellular functions, biocompatibility, capability of waste and nutrient transport, and sufficient structural integrity for joint reconstruction. Both natural and synthetic materials are applied as cartilage tissue engineering scaffolds in a variety of forms, including fibrous structures, porous sponges, woven or nonwoven meshes, and hydrogels. Biological factors are commonly applied to guide cellular differentiation, migration, adhesion, and gene expression. These factors include soluble biochemical signals, transfection of gene vectors, and cell-cell interactions. Soluble signaling molecules are used to instruct cells to proliferate, differentiate, and generate cartilage matrix during cartilage tissue reconstruction. The signaling molecules of growth factors are investigated intensively, especially TGFβ superfamily, several bone morphogenetic protein (BMPs), insulin-like growth factor (IGF)-1, fibroblast growth factors (FGFs), and epidermal growth factor (EGF). Gene therapy techniques are developed to deliver therapeutic genes encoding necessary gene products to cells at the site of cartilage injury to synthesize biological factors of interest for sustained local expression. Bioreactors are developed to provide adequate mass transfer and mechanical stimulation in order to enhance the biochemical and mechanical properties of engineered cartilage tissues.",
author = "Qiongyu Guo and Elisseeff, {Jennifer Hartt}",
year = "2011",
doi = "10.1016/B978-0-12-381422-7.10053-7",
language = "English (US)",
isbn = "9780123814227",
pages = "981--995",
booktitle = "Principles of Regenerative Medicine",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Cartilage Tissue Engineering

AU - Guo, Qiongyu

AU - Elisseeff, Jennifer Hartt

PY - 2011

Y1 - 2011

N2 - This chapter provides an introduction to tissue engineering for cartilage repair. Tissue engineering scaffolds are designed to provide a 3D environment to support and direct cellular processes in their migration, proliferation, and differentiation toward functional tissue. The selection of bioscaffolds for cartilage engineering requires excellent mechanical properties to support cellular functions, biocompatibility, capability of waste and nutrient transport, and sufficient structural integrity for joint reconstruction. Both natural and synthetic materials are applied as cartilage tissue engineering scaffolds in a variety of forms, including fibrous structures, porous sponges, woven or nonwoven meshes, and hydrogels. Biological factors are commonly applied to guide cellular differentiation, migration, adhesion, and gene expression. These factors include soluble biochemical signals, transfection of gene vectors, and cell-cell interactions. Soluble signaling molecules are used to instruct cells to proliferate, differentiate, and generate cartilage matrix during cartilage tissue reconstruction. The signaling molecules of growth factors are investigated intensively, especially TGFβ superfamily, several bone morphogenetic protein (BMPs), insulin-like growth factor (IGF)-1, fibroblast growth factors (FGFs), and epidermal growth factor (EGF). Gene therapy techniques are developed to deliver therapeutic genes encoding necessary gene products to cells at the site of cartilage injury to synthesize biological factors of interest for sustained local expression. Bioreactors are developed to provide adequate mass transfer and mechanical stimulation in order to enhance the biochemical and mechanical properties of engineered cartilage tissues.

AB - This chapter provides an introduction to tissue engineering for cartilage repair. Tissue engineering scaffolds are designed to provide a 3D environment to support and direct cellular processes in their migration, proliferation, and differentiation toward functional tissue. The selection of bioscaffolds for cartilage engineering requires excellent mechanical properties to support cellular functions, biocompatibility, capability of waste and nutrient transport, and sufficient structural integrity for joint reconstruction. Both natural and synthetic materials are applied as cartilage tissue engineering scaffolds in a variety of forms, including fibrous structures, porous sponges, woven or nonwoven meshes, and hydrogels. Biological factors are commonly applied to guide cellular differentiation, migration, adhesion, and gene expression. These factors include soluble biochemical signals, transfection of gene vectors, and cell-cell interactions. Soluble signaling molecules are used to instruct cells to proliferate, differentiate, and generate cartilage matrix during cartilage tissue reconstruction. The signaling molecules of growth factors are investigated intensively, especially TGFβ superfamily, several bone morphogenetic protein (BMPs), insulin-like growth factor (IGF)-1, fibroblast growth factors (FGFs), and epidermal growth factor (EGF). Gene therapy techniques are developed to deliver therapeutic genes encoding necessary gene products to cells at the site of cartilage injury to synthesize biological factors of interest for sustained local expression. Bioreactors are developed to provide adequate mass transfer and mechanical stimulation in order to enhance the biochemical and mechanical properties of engineered cartilage tissues.

UR - http://www.scopus.com/inward/record.url?scp=84882081969&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882081969&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-381422-7.10053-7

DO - 10.1016/B978-0-12-381422-7.10053-7

M3 - Chapter

AN - SCOPUS:84882081969

SN - 9780123814227

SP - 981

EP - 995

BT - Principles of Regenerative Medicine

PB - Elsevier Inc.

ER -