Carrier-specific unresponsiveness in reaginic antibody formation. I. Induction of helper cell tolerance in rats

Fred Sanfilippo, David W. Scott

Research output: Contribution to journalArticlepeer-review

Abstract

Rats pretreated with 10 mg soluble sheep gamma globulin (soluble SGG or SGGSo) showed a marked reduction in IgE anti-TNP antibody upon challenge with TNP-SGG in alum. This effect was found to be carrier-specific since SGGSo tolerant rats gave normal IgE anti-TNP responses when challenged with TNP-KLH. Carrier tolerance persisted when a secondary challenge with TNP-SGG was given. The degree of tolerance induction was shown to be tolerogen dose-dependent. As expected, IgE anti-SGG responses were also reduced in this system by pretreatment with SGGSo. These results indicate that carrier-specific helper cells for IgE antibody responses can be rendered functionally unresponsive. However, in contrast to the long duration of carrier-specific tolerance for IgM and IgG responses, IgE tolerance in this system appeared to be only short-lived. This difference suggests that IgE helper and/or suppressor T cells may represent a separate subclass from those involved in IgM and IgG responses.

Original languageEnglish (US)
Pages (from-to)427-434
Number of pages8
JournalCellular Immunology
Volume28
Issue number2
DOIs
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Fingerprint Dive into the research topics of 'Carrier-specific unresponsiveness in reaginic antibody formation. I. Induction of helper cell tolerance in rats'. Together they form a unique fingerprint.

Cite this