Carotid plaque morphologic characteristics.

Gilbert Aidinian, Jonathan M. Weiswasser, Subodh Arora, Christopher Joseph Abularrage, Niten Singh, Anton N. Sidawy

Research output: Contribution to journalArticle

Abstract

Carotid artery atherosclerosis is predominantly believed to mirror atherosclerosis elsewhere in the body. Endothelial injury results in expression of cell surface adhesion molecules with expression of sequence of genes involved in the inflammatory pathway and expression of proinflammatory cytokines. The combination of the inflammatory mediators and contribution by monocytes infiltrating the intima and vascular smooth muscle cell proliferation result in the development of atheromatous plaque with a lipid-rich necrotic core. Complications of these atheromatous plaques can lead to plaque instability, rupture, and subsequent hemorrhage or ulceration. The significant risk factors, characteristics associated with symptoms, and available diagnostic imaging modalities are also discussed with review of the relevant literature.

Original languageEnglish (US)
Pages (from-to)63-70
Number of pages8
JournalPerspectives in Vascular Surgery and Endovascular Therapy
Volume18
Issue number1
DOIs
StatePublished - Mar 2006
Externally publishedYes

Fingerprint

Atherosclerotic Plaques
Carotid Artery Diseases
Cell Adhesion Molecules
Diagnostic Imaging
Vascular Smooth Muscle
Carotid Arteries
Smooth Muscle Myocytes
Rupture
Monocytes
Atherosclerosis
Cell Proliferation
Hemorrhage
Cytokines
Lipids
Gene Expression
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Carotid plaque morphologic characteristics. / Aidinian, Gilbert; Weiswasser, Jonathan M.; Arora, Subodh; Abularrage, Christopher Joseph; Singh, Niten; Sidawy, Anton N.

In: Perspectives in Vascular Surgery and Endovascular Therapy, Vol. 18, No. 1, 03.2006, p. 63-70.

Research output: Contribution to journalArticle

Aidinian, Gilbert ; Weiswasser, Jonathan M. ; Arora, Subodh ; Abularrage, Christopher Joseph ; Singh, Niten ; Sidawy, Anton N. / Carotid plaque morphologic characteristics. In: Perspectives in Vascular Surgery and Endovascular Therapy. 2006 ; Vol. 18, No. 1. pp. 63-70.
@article{497be2fa1bfe49769f2bf2e1be89c8d3,
title = "Carotid plaque morphologic characteristics.",
abstract = "Carotid artery atherosclerosis is predominantly believed to mirror atherosclerosis elsewhere in the body. Endothelial injury results in expression of cell surface adhesion molecules with expression of sequence of genes involved in the inflammatory pathway and expression of proinflammatory cytokines. The combination of the inflammatory mediators and contribution by monocytes infiltrating the intima and vascular smooth muscle cell proliferation result in the development of atheromatous plaque with a lipid-rich necrotic core. Complications of these atheromatous plaques can lead to plaque instability, rupture, and subsequent hemorrhage or ulceration. The significant risk factors, characteristics associated with symptoms, and available diagnostic imaging modalities are also discussed with review of the relevant literature.",
author = "Gilbert Aidinian and Weiswasser, {Jonathan M.} and Subodh Arora and Abularrage, {Christopher Joseph} and Niten Singh and Sidawy, {Anton N.}",
year = "2006",
month = "3",
doi = "10.1177/153100350601800124",
language = "English (US)",
volume = "18",
pages = "63--70",
journal = "Perspectives in Vascular Surgery and Endovascular Therapy",
issn = "1531-0035",
publisher = "SAGE Publications Inc.",
number = "1",

}

TY - JOUR

T1 - Carotid plaque morphologic characteristics.

AU - Aidinian, Gilbert

AU - Weiswasser, Jonathan M.

AU - Arora, Subodh

AU - Abularrage, Christopher Joseph

AU - Singh, Niten

AU - Sidawy, Anton N.

PY - 2006/3

Y1 - 2006/3

N2 - Carotid artery atherosclerosis is predominantly believed to mirror atherosclerosis elsewhere in the body. Endothelial injury results in expression of cell surface adhesion molecules with expression of sequence of genes involved in the inflammatory pathway and expression of proinflammatory cytokines. The combination of the inflammatory mediators and contribution by monocytes infiltrating the intima and vascular smooth muscle cell proliferation result in the development of atheromatous plaque with a lipid-rich necrotic core. Complications of these atheromatous plaques can lead to plaque instability, rupture, and subsequent hemorrhage or ulceration. The significant risk factors, characteristics associated with symptoms, and available diagnostic imaging modalities are also discussed with review of the relevant literature.

AB - Carotid artery atherosclerosis is predominantly believed to mirror atherosclerosis elsewhere in the body. Endothelial injury results in expression of cell surface adhesion molecules with expression of sequence of genes involved in the inflammatory pathway and expression of proinflammatory cytokines. The combination of the inflammatory mediators and contribution by monocytes infiltrating the intima and vascular smooth muscle cell proliferation result in the development of atheromatous plaque with a lipid-rich necrotic core. Complications of these atheromatous plaques can lead to plaque instability, rupture, and subsequent hemorrhage or ulceration. The significant risk factors, characteristics associated with symptoms, and available diagnostic imaging modalities are also discussed with review of the relevant literature.

UR - http://www.scopus.com/inward/record.url?scp=33746096586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746096586&partnerID=8YFLogxK

U2 - 10.1177/153100350601800124

DO - 10.1177/153100350601800124

M3 - Article

C2 - 16628337

AN - SCOPUS:33746096586

VL - 18

SP - 63

EP - 70

JO - Perspectives in Vascular Surgery and Endovascular Therapy

JF - Perspectives in Vascular Surgery and Endovascular Therapy

SN - 1531-0035

IS - 1

ER -