Carotid chemoreceptor response to intermittent or sustained stimulation in the cat

Robert S. Fitzgerald, Louis Michel Leitner, Marie Joëlle Llaubet

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


In order to determine how closely the carotid chemoreceptor system follows a repeated transient stimulus, intermittent infusions of hypercapnic-hypoxic, hypercapnic, and hypoxic blood were made into the common carotid arteries of anesthetized, artificially ventilated cats. The system demonstrated an ability to follow blood-home stimuli presented at frequencies up to about 70 min-1 though at decreasing amplitude. In response to sustained stimulations, the carotid body showed a slow adaptation to hypercapnic stimuli and perhaps to hypoxic stimuli also. A transient undershoot occurred at the cessation of stimulation when the animal was breathing air, an event generally not seen if the animal was breathing pure oxygen.

Original languageEnglish (US)
Pages (from-to)395-402
Number of pages8
JournalRespiration Physiology
Issue number3
StatePublished - Apr 1969
Externally publishedYes


  • Arterial chemoreceptor
  • Asphyxia
  • Control of breathing
  • Hypercapnia
  • Hypoxia
  • Regulation of respiration
  • Sinus nerve

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Carotid chemoreceptor response to intermittent or sustained stimulation in the cat'. Together they form a unique fingerprint.

Cite this