TY - JOUR
T1 - Carotid chemoreceptor response to intermittent or sustained stimulation in the cat
AU - Fitzgerald, Robert S.
AU - Leitner, Louis Michel
AU - Llaubet, Marie Joëlle
N1 - Funding Information:
lsupported by grants from Centre National de la Recherche Scientifique and D.G.R.S.T., contract No 6600439. 2 On leave of absence from the Department of Environmental Medicine, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, U.S.A. * Reprint request: Dr. L.-M. Leitner, 129 rue de Tolbiac, 75-Paris 13, France.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1969/4
Y1 - 1969/4
N2 - In order to determine how closely the carotid chemoreceptor system follows a repeated transient stimulus, intermittent infusions of hypercapnic-hypoxic, hypercapnic, and hypoxic blood were made into the common carotid arteries of anesthetized, artificially ventilated cats. The system demonstrated an ability to follow blood-home stimuli presented at frequencies up to about 70 min-1 though at decreasing amplitude. In response to sustained stimulations, the carotid body showed a slow adaptation to hypercapnic stimuli and perhaps to hypoxic stimuli also. A transient undershoot occurred at the cessation of stimulation when the animal was breathing air, an event generally not seen if the animal was breathing pure oxygen.
AB - In order to determine how closely the carotid chemoreceptor system follows a repeated transient stimulus, intermittent infusions of hypercapnic-hypoxic, hypercapnic, and hypoxic blood were made into the common carotid arteries of anesthetized, artificially ventilated cats. The system demonstrated an ability to follow blood-home stimuli presented at frequencies up to about 70 min-1 though at decreasing amplitude. In response to sustained stimulations, the carotid body showed a slow adaptation to hypercapnic stimuli and perhaps to hypoxic stimuli also. A transient undershoot occurred at the cessation of stimulation when the animal was breathing air, an event generally not seen if the animal was breathing pure oxygen.
KW - Arterial chemoreceptor
KW - Asphyxia
KW - Control of breathing
KW - Hypercapnia
KW - Hypoxia
KW - Regulation of respiration
KW - Sinus nerve
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U2 - 10.1016/0034-5687(69)90037-1
DO - 10.1016/0034-5687(69)90037-1
M3 - Article
C2 - 5778484
AN - SCOPUS:0014492770
VL - 6
SP - 395
EP - 402
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
IS - 3
ER -