Carotid artery wall thickness and risk of stroke subtypes: The atherosclerosis risk in communities study

Tetsuya Ohira, Eyal Shahar, Hiroyasu Iso, Lloyd E. Chambless, Wayne D. Rosamond, A. Richey Sharrett, Aaron R. Folsom

Research output: Contribution to journalArticle

Abstract

Background and Purpose- Understanding associations of carotid atherosclerosis with stroke subtypes may contribute to more effective prevention of stroke. Methods- Between 1987 and 1989, 13 560 men and women aged 45 to 64 years and free of clinical stroke took part in the first examination of the Atherosclerosis Risk in Communities (ARIC) study. Incident strokes were ascertained by hospital surveillance. Results- During an average follow-up of 15.7 years, 82 incident hemorrhagic and 621 incident ischemic strokes (131 lacunar, 358 nonlacunar, and 132 cardioembolic strokes) occurred. The incidence rates of hemorrhagic and ischemic strokes were greater across higher carotid intima-media thickness levels. Although this positive association was observed for all stroke subtypes, the age-, gender-, and race-adjusted risk ratios were higher for cardioembolic and nonlacunar strokes than for hemorrhagic and lacunar strokes. Compared with participants in the lowest quintile (

Original languageEnglish (US)
Pages (from-to)397-403
Number of pages7
JournalStroke
Volume42
Issue number2
DOIs
StatePublished - Feb 2011

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Keywords

  • brain infarction
  • carotid artery
  • epidemiology
  • intima-media thickness
  • stroke subtypes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Ohira, T., Shahar, E., Iso, H., Chambless, L. E., Rosamond, W. D., Sharrett, A. R., & Folsom, A. R. (2011). Carotid artery wall thickness and risk of stroke subtypes: The atherosclerosis risk in communities study. Stroke, 42(2), 397-403. https://doi.org/10.1161/STROKEAHA.110.592261