TY - JOUR
T1 - Carotid artery ultrasound texture, cardiovascular risk factors, and subclinical arterial disease
T2 - The multi-ethnic study of atherosclerosis (MeSA)
AU - Mitchell, Carol C.
AU - Korcarz, Claudia E.
AU - Tattersall, Matthew C.
AU - Gepner, Adam D.
AU - Young, Rebekah L.
AU - Post, Wendy S.
AU - Kaufman, Joel D.
AU - McClelland, Robyn L.
AU - Stein, James H.
N1 - Funding Information:
This work was supported by the American Heart Association (AHA) Midwest Grant-In-Aid: 16GRNT29090009. This research also was supported by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 from the National Heart, Lung, and Blood Institute, and by grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from NCATS. The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org. This publication also was developed under a STAR research assistance agreement, No. RD831697 (MESA Air), awarded by the U.S Environmental Protection Agency. It has not been formally reviewed by the EPA. The views expressed in this document are solely those of the authors and the EPA does not endorse any products or commercial services mentioned in this publication.
Publisher Copyright:
© 2018 British Institute of Radiology. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Objective: This pilot study determined if the ultrasound texture feature “contrast” was associated with cardiovascular disease (CVD) risk factors and subclinical arterial disease. Methods: We evaluated ultrasound images of the right common carotid artery (CCA) from a convenience sample of 151 participants and examined relationships between contrast, CVD risk factors, carotid intima-media thickness (IMT) and coronary artery calcium (CAC). Grey level difference statistics algorithms were used to evaluate the texture feature “contrast” from carotid ultrasound images. Right CCA IMT measurements were made in triplicate in the distal 1 cm segment of the far wall of the artery and CAC score was measured using the Agatston scoring method. Results: In individual models that included age, sex and race, grey level difference statistics contrast (outcome) was associated independently with age [beta (standard error) = −0.87 (0.38) per year; p = 0.02], C-reactive protein [−2.22 (0.96) per mg dl–1; p = 0.02], high-density lipoprotein cholesterol [0.61 (0.24) per mg dl–1; p = 0.01] and CCA IMT [−0.06 (0.02) microns; p = 0.001]. Other CVD risk factors and CAC were not associated independently with contrast. Conclusion: These findings support the potential use of the ultrasound texture contrast for evaluating arterial injury and CVD risk. Advances in knowledge: This paper contributes to the literature in that it describes how the greyscale texture feature “contrast” is related to CVD risk factors.
AB - Objective: This pilot study determined if the ultrasound texture feature “contrast” was associated with cardiovascular disease (CVD) risk factors and subclinical arterial disease. Methods: We evaluated ultrasound images of the right common carotid artery (CCA) from a convenience sample of 151 participants and examined relationships between contrast, CVD risk factors, carotid intima-media thickness (IMT) and coronary artery calcium (CAC). Grey level difference statistics algorithms were used to evaluate the texture feature “contrast” from carotid ultrasound images. Right CCA IMT measurements were made in triplicate in the distal 1 cm segment of the far wall of the artery and CAC score was measured using the Agatston scoring method. Results: In individual models that included age, sex and race, grey level difference statistics contrast (outcome) was associated independently with age [beta (standard error) = −0.87 (0.38) per year; p = 0.02], C-reactive protein [−2.22 (0.96) per mg dl–1; p = 0.02], high-density lipoprotein cholesterol [0.61 (0.24) per mg dl–1; p = 0.01] and CCA IMT [−0.06 (0.02) microns; p = 0.001]. Other CVD risk factors and CAC were not associated independently with contrast. Conclusion: These findings support the potential use of the ultrasound texture contrast for evaluating arterial injury and CVD risk. Advances in knowledge: This paper contributes to the literature in that it describes how the greyscale texture feature “contrast” is related to CVD risk factors.
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U2 - 10.1259/bjr.20170637
DO - 10.1259/bjr.20170637
M3 - Review article
C2 - 29308915
AN - SCOPUS:85044697955
SN - 0007-1285
VL - 91
JO - British Journal of Radiology
JF - British Journal of Radiology
IS - 1084
M1 - 20170637
ER -