Carotid Artery Tortuosity Index Is Associated with the Need for Early Aortic Root Replacement in Patients with Loeys-Dietz Syndrome

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Abstract

Objective This study aimed to determine if carotid arterial tortuosity represents a marker of disease severity in Loeys-Dietz syndrome (LDS). Methods Fifty-four 54 LDS patients (mean age, 17.0 years) who underwent computed tomogram angiography from January 2004 to December 2013 were retrospectively identified. Carotid artery tortuosity index (CATI) was calculated from computed tomogram angiography. Clinical variables were obtained from the medical records. Relationship between CATI and need for aortic root replacement was evaluated with Cox proportional hazard model and Kaplan-Meier analysis. Results Higher CATI was associated with the need for aortic root replacement (P < 0.001) in the univariate Cox proportional hazard model. Patients were stratified based on both CATI and aortic root size in Kaplan-Meier analysis, and patients with higher CATI were more likely to require aortic root replacement (P < 0.001) in both aortic root size strata. Conclusion Increased carotid artery tortuosity is associated with the need for early aortic root replacement in patients with LDS.

Original languageEnglish (US)
Pages (from-to)747-753
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume42
Issue number5
DOIs
StatePublished - Sep 1 2018

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Loeys-Dietz Syndrome
Carotid Arteries
Kaplan-Meier Estimate
Proportional Hazards Models
Angiography
Medical Records

Keywords

  • aortic root replacement
  • arterial tortuosity
  • CT angiography
  • Loeys-Dietz syndrome

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{99442978ccaa4a079599813f0f63c114,
title = "Carotid Artery Tortuosity Index Is Associated with the Need for Early Aortic Root Replacement in Patients with Loeys-Dietz Syndrome",
abstract = "Objective This study aimed to determine if carotid arterial tortuosity represents a marker of disease severity in Loeys-Dietz syndrome (LDS). Methods Fifty-four 54 LDS patients (mean age, 17.0 years) who underwent computed tomogram angiography from January 2004 to December 2013 were retrospectively identified. Carotid artery tortuosity index (CATI) was calculated from computed tomogram angiography. Clinical variables were obtained from the medical records. Relationship between CATI and need for aortic root replacement was evaluated with Cox proportional hazard model and Kaplan-Meier analysis. Results Higher CATI was associated with the need for aortic root replacement (P < 0.001) in the univariate Cox proportional hazard model. Patients were stratified based on both CATI and aortic root size in Kaplan-Meier analysis, and patients with higher CATI were more likely to require aortic root replacement (P < 0.001) in both aortic root size strata. Conclusion Increased carotid artery tortuosity is associated with the need for early aortic root replacement in patients with LDS.",
keywords = "aortic root replacement, arterial tortuosity, CT angiography, Loeys-Dietz syndrome",
author = "Chu, {Linda Chi Hang} and Haroun, {Reham R.} and Beaulieu, {Robert J.} and Black, {James Hamilton} and Dietz, {Harry C} and Fishman, {Elliot K}",
year = "2018",
month = "9",
day = "1",
doi = "10.1097/RCT.0000000000000764",
language = "English (US)",
volume = "42",
pages = "747--753",
journal = "Journal of Computer Assisted Tomography",
issn = "0363-8715",
publisher = "Lippincott Williams and Wilkins",
number = "5",

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TY - JOUR

T1 - Carotid Artery Tortuosity Index Is Associated with the Need for Early Aortic Root Replacement in Patients with Loeys-Dietz Syndrome

AU - Chu, Linda Chi Hang

AU - Haroun, Reham R.

AU - Beaulieu, Robert J.

AU - Black, James Hamilton

AU - Dietz, Harry C

AU - Fishman, Elliot K

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Objective This study aimed to determine if carotid arterial tortuosity represents a marker of disease severity in Loeys-Dietz syndrome (LDS). Methods Fifty-four 54 LDS patients (mean age, 17.0 years) who underwent computed tomogram angiography from January 2004 to December 2013 were retrospectively identified. Carotid artery tortuosity index (CATI) was calculated from computed tomogram angiography. Clinical variables were obtained from the medical records. Relationship between CATI and need for aortic root replacement was evaluated with Cox proportional hazard model and Kaplan-Meier analysis. Results Higher CATI was associated with the need for aortic root replacement (P < 0.001) in the univariate Cox proportional hazard model. Patients were stratified based on both CATI and aortic root size in Kaplan-Meier analysis, and patients with higher CATI were more likely to require aortic root replacement (P < 0.001) in both aortic root size strata. Conclusion Increased carotid artery tortuosity is associated with the need for early aortic root replacement in patients with LDS.

AB - Objective This study aimed to determine if carotid arterial tortuosity represents a marker of disease severity in Loeys-Dietz syndrome (LDS). Methods Fifty-four 54 LDS patients (mean age, 17.0 years) who underwent computed tomogram angiography from January 2004 to December 2013 were retrospectively identified. Carotid artery tortuosity index (CATI) was calculated from computed tomogram angiography. Clinical variables were obtained from the medical records. Relationship between CATI and need for aortic root replacement was evaluated with Cox proportional hazard model and Kaplan-Meier analysis. Results Higher CATI was associated with the need for aortic root replacement (P < 0.001) in the univariate Cox proportional hazard model. Patients were stratified based on both CATI and aortic root size in Kaplan-Meier analysis, and patients with higher CATI were more likely to require aortic root replacement (P < 0.001) in both aortic root size strata. Conclusion Increased carotid artery tortuosity is associated with the need for early aortic root replacement in patients with LDS.

KW - aortic root replacement

KW - arterial tortuosity

KW - CT angiography

KW - Loeys-Dietz syndrome

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