Careful histological confirmation and microdissection reveal telomerase activity in otherwise telomerase-negative breast cancers

Lisa A. Carey, Catigan A. Hedican, Gregory S. Henderson, Christopher B Umbricht, Jeffrey S. Dome, Debora Varon, Saraswati Sukumar

Research output: Contribution to journalArticle

Abstract

Studies of invasive breast cancers consistently identify a subset of tumors without telomerase activity, compromising its utility as a tumor marker. Telomerase-negative tumors may represent a biologically different subset, or the result could be attributed to assay imperfections. To resolve this issue, we tested 105 invasive breast cancers for telomerase activity and found that 23 (22%) tumors were telomerase negative. Careful histological confirmation of an adjacent cryosection and/or microdissection of pure tumor cells reduced this number to 5 (5%). Thus, truly telomerase-negative invasive breast cancers are rare, making this enzyme a potentially very useful tumor marker in breast cancer.

Original languageEnglish (US)
Pages (from-to)435-440
Number of pages6
JournalClinical Cancer Research
Volume4
Issue number2
StatePublished - Feb 1998

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Microdissection
Telomerase
Breast Neoplasms
Tumor Biomarkers
Neoplasms
Cell Count
Enzymes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Careful histological confirmation and microdissection reveal telomerase activity in otherwise telomerase-negative breast cancers. / Carey, Lisa A.; Hedican, Catigan A.; Henderson, Gregory S.; Umbricht, Christopher B; Dome, Jeffrey S.; Varon, Debora; Sukumar, Saraswati.

In: Clinical Cancer Research, Vol. 4, No. 2, 02.1998, p. 435-440.

Research output: Contribution to journalArticle

Carey, Lisa A. ; Hedican, Catigan A. ; Henderson, Gregory S. ; Umbricht, Christopher B ; Dome, Jeffrey S. ; Varon, Debora ; Sukumar, Saraswati. / Careful histological confirmation and microdissection reveal telomerase activity in otherwise telomerase-negative breast cancers. In: Clinical Cancer Research. 1998 ; Vol. 4, No. 2. pp. 435-440.
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