Cardiovascular risk prevalence in South Africans with drug-resistant tuberculosis: a cross-sectional study

E. R. Whitehouse, Nancy A Perrin, N. Levitt, Martha Hill, Jason Farley

Research output: Contribution to journalArticlepeer-review


<sec id="st1"> <title>BACKGROUND</title> In South Africa, the risk factors for cardiovascular disease (CVD) are increasing, thereby impacting patients with drug-resistant tuberculosis (DR-TB). </sec> <sec id="st2"> <title>OBJECTIVE</title> To determine the prevalence of traditional CVD risk factors (diabetes mellitus [DM], smoking, hypertension, increased body mass index [BMI]) and a total risk score for CVD among patients with DR-TB. </sec> <sec id="st3"> <title>METHODS</title> This cross-sectional study was nested within an ongoing cluster-randomized trial in 10 DR-TB hospitals in South Africa. The data for the present study were collected between November 2014 and July 2016. </sec> <sec id="st4"> <title>RESULTS</title> Of 900 participants aged 18 years, 75.1% were co-infected with the human immunodeficiency virus (HIV), and 52.3% had one or more CVD risk factors. The prevalence of CVD risk factors was hypertension (16.7%), increased BMI (16.6%), DM (5.2%), and smoking (31.4%). Among patients with DM or hypertension, 58.8-95.5% had additional comorbid CVD risk factors. Of 398 participants eligible for the CVD risk score (age 35 years), 23.4% had a moderate or high CVD risk score. </sec> <sec id="st5"> <title>CONCLUSION</title> Patients with multiple diseases, including DR-TB and HIV, with traditional CVD risk factors, may have higher risks for negative outcomes during treatment for DR-TB. TB providers should identify people at risk to initiate primary and secondary prevention to improve outcomes. </sec>.

Original languageEnglish (US)
Pages (from-to)587-593
Number of pages7
JournalThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Issue number5
StatePublished - May 1 2019

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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