Abstract
Rising rates of both type 1 and type 2 diabetes mellitus in children have led to increased concern regarding cardiovascular disease (CVD) risk during childhood. Diabetic children face prolonged exposure to hyperglycemia, and have increased risk of both microvascular and macrovascular disease. These circumstances may result in a generation of young adults presenting with cardiovascular outcomes, a tremendous personal and public health toll. In this article, we review CVD risk in type 1 and type 2 diabetes, discuss aspects of pathophysiology, and review current methods of CVD risk assessment. We also identify crucial areas in need of future research in order to devise effective prevention and treatment of CVD risk in children.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 591-600 |
| Number of pages | 10 |
| Journal | Current Cardiovascular Risk Reports |
| Volume | 6 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2012 |
| Externally published | Yes |
Keywords
- Adipokines
- Adiponectin
- Body mass index
- Cardiovascular risk
- Carotid intimal medial thickness
- Coronary artery calcification
- Echocardiography
- Flow mediated dilation of the brachial artery
- Inflammation
- Left ventricular mass
- Lipids
- Lipoprotein subclass particle analysis
- Obesity
- Pediatrics
- Pulse wave analysis
- Pulse wave velocity
- Type 1 diabetes mellitus
- Type 2 diabetes mellitus
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)