Abstract
Vagally mediated tachycardia appears to be a common response to abused drugs and, therefore, has implications for abuse liability. To test the specificity of this common factor, we determined whether the tachycardia to naloxone in opiate-dependent individuals has a significant vagal component. Naloxone challenge (0.4 mg, IM) in 19 opiate-dependent men and women was associated with highly reliable tachycardia, but no significant change in vagal tone index, a noninvasive measure of parasympathetic inhibitory control of the heart. We conclude that tachycardia during naloxone-precipitated withdrawal is not vagally mediated. Thus, there is some degree of specificity to the common factor of vagally mediated tachycardia to abused drugs because it was ruled out in at least one drug (naloxone) with aversive subjective effects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 357-360 |
| Number of pages | 4 |
| Journal | Pharmacology Biochemistry and Behavior |
| Volume | 43 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1992 |
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Keywords
- Abused drugs
- Heart rate
- Naloxone
- Opiate withdrawal
- Parasympathetic
- Sympathetic
- Vagal tone
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Cardiovascular responses to naloxone challenge in opiate-dependent individuals. / Newlin, David B.; Wong, Conrad J.; Cheskin, Lawrence J.
In: Pharmacology Biochemistry and Behavior, Vol. 43, No. 2, 1992, p. 357-360.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiovascular responses to naloxone challenge in opiate-dependent individuals
AU - Newlin, David B.
AU - Wong, Conrad J.
AU - Cheskin, Lawrence J
PY - 1992
Y1 - 1992
N2 - Vagally mediated tachycardia appears to be a common response to abused drugs and, therefore, has implications for abuse liability. To test the specificity of this common factor, we determined whether the tachycardia to naloxone in opiate-dependent individuals has a significant vagal component. Naloxone challenge (0.4 mg, IM) in 19 opiate-dependent men and women was associated with highly reliable tachycardia, but no significant change in vagal tone index, a noninvasive measure of parasympathetic inhibitory control of the heart. We conclude that tachycardia during naloxone-precipitated withdrawal is not vagally mediated. Thus, there is some degree of specificity to the common factor of vagally mediated tachycardia to abused drugs because it was ruled out in at least one drug (naloxone) with aversive subjective effects.
AB - Vagally mediated tachycardia appears to be a common response to abused drugs and, therefore, has implications for abuse liability. To test the specificity of this common factor, we determined whether the tachycardia to naloxone in opiate-dependent individuals has a significant vagal component. Naloxone challenge (0.4 mg, IM) in 19 opiate-dependent men and women was associated with highly reliable tachycardia, but no significant change in vagal tone index, a noninvasive measure of parasympathetic inhibitory control of the heart. We conclude that tachycardia during naloxone-precipitated withdrawal is not vagally mediated. Thus, there is some degree of specificity to the common factor of vagally mediated tachycardia to abused drugs because it was ruled out in at least one drug (naloxone) with aversive subjective effects.
KW - Abused drugs
KW - Heart rate
KW - Naloxone
KW - Opiate withdrawal
KW - Parasympathetic
KW - Sympathetic
KW - Vagal tone
UR - http://www.scopus.com/inward/record.url?scp=0026454604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026454604&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(92)90162-9
DO - 10.1016/0091-3057(92)90162-9
M3 - Article
C2 - 1332078
AN - SCOPUS:0026454604
VL - 43
SP - 357
EP - 360
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
SN - 0091-3057
IS - 2
ER -