Cardiovascular responses to arterial hypoxia in awake sinoaortic denervated dogs

J. A. Krasney, M. G. Magno, M. G. Levitzky, Raymond C Koehler, D. G. Davies

Research output: Contribution to journalArticle

Abstract

In the conscious, intact, instrumented dog exposure to 6 min of arterial hypoxia (Pao 24.5 mm Hg) by a mask caused a 79% increase in cardiac output, a 61% rise in heart rate, and a 22% rise in blood pressure. Ventilation increased 323%, causing hypocapnia and an increase in arterial pH. The carotid and aortic depressor nerves were then sectioned, and after a several day recovery period the effect of hypoxia was again tested. After denervation, similar levels of arterial hypoxia caused a 64% rise in cardiac output, a 23% rise in heart rate, and no change in blood pressure. There was a slight but significant increase in ventilation (20%) along with no appreciable changes in arterial pH or PCO 2. These data indicate that blood pressure is relatively well maintained during hypoxia in the awake dog after chemodenervation in contrast to the marked fall in blood pressure observed under these conditions in anesthetized dogs. Moreover, it is apparent that a large part of the cardiac output response of the intact animal is initiated outside the sinoaortic zones.

Original languageEnglish (US)
Pages (from-to)733-738
Number of pages6
JournalJournal of Applied Physiology
Volume35
Issue number5
StatePublished - 1973
Externally publishedYes

Fingerprint

Cardiac Output
Dogs
Blood Pressure
Ventilation
Heart Rate
Hypocapnia
Nerve Block
Denervation
Masks
Hypoxia

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Krasney, J. A., Magno, M. G., Levitzky, M. G., Koehler, R. C., & Davies, D. G. (1973). Cardiovascular responses to arterial hypoxia in awake sinoaortic denervated dogs. Journal of Applied Physiology, 35(5), 733-738.

Cardiovascular responses to arterial hypoxia in awake sinoaortic denervated dogs. / Krasney, J. A.; Magno, M. G.; Levitzky, M. G.; Koehler, Raymond C; Davies, D. G.

In: Journal of Applied Physiology, Vol. 35, No. 5, 1973, p. 733-738.

Research output: Contribution to journalArticle

Krasney, JA, Magno, MG, Levitzky, MG, Koehler, RC & Davies, DG 1973, 'Cardiovascular responses to arterial hypoxia in awake sinoaortic denervated dogs', Journal of Applied Physiology, vol. 35, no. 5, pp. 733-738.
Krasney, J. A. ; Magno, M. G. ; Levitzky, M. G. ; Koehler, Raymond C ; Davies, D. G. / Cardiovascular responses to arterial hypoxia in awake sinoaortic denervated dogs. In: Journal of Applied Physiology. 1973 ; Vol. 35, No. 5. pp. 733-738.
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