Cardiovascular magnetic resonance myocardial feature tracking for quantitative viability assessment in ischemic cardiomyopathy

Andreas Schuster; Matthias Paul; Nuno Bettencourt; Geraint Morton; Amedeo Chiribiri; Masaki Ishida; Shazia Hussain; Roy Jogiya; Shelby Kutty; Boris Bigalke; Divaka Perera; Eike Nagel

doi:10.1016/j.ijcard.2011.10.137

Cardiovascular magnetic resonance myocardial feature tracking for quantitative viability assessment in ischemic cardiomyopathy

Andreas Schuster, Matthias Paul, Nuno Bettencourt, Geraint Morton, Amedeo Chiribiri, Masaki Ishida, Shazia Hussain, Roy Jogiya, Shelby Kutty, Boris Bigalke, Divaka Perera, Eike Nagel

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Background: Low dose dobutamine stress magnetic resonance imaging is valuable to assess viability in patients with ischemic cardiomyopathy. Analysis is usually qualitative with considerable operator dependency. The aim of the current study was to investigate the feasibility of cine images derived quantitative cardiac magnetic resonance (CMR) myocardial feature tracking (FT) strain parameters to assess viability in patients with ischemic cardiomyopathy. Methods: 15 consecutive patients with ischemic cardiomyopathy referred for viability assessment were studied at 3 T at rest and during low dose dobutamine stress (5 and 10 μg/kg/min of dobutamine). Subendocardial and subepicardial circumferential (Ecc_endo and Ecc_epi) and radial (Err) strains were assessed using steady state free precession (SSFP) cine images orientated in 3 short axis slices covering 16 myocardial segments. Results: Dysfunctional segments without scar (n = 75) improved in all three strain parameters: Ecc_endo (Rest: - 10.5 ± 6.9; 5 μg: - 12.1 ± 6.9; 10 μg: - 14.1 ± 9.2; p < 0.05), Ecc_epi (Rest: - 7 ± 4.8; 5 μg: - 8.2 ± 5.5; 10 μg: - 9.1 ± 5.9; p < 0.05) and Err (Rest: 11.7 ± 8.3; 5 μg: 16 ± 10.9; 10 μg: 16.5 ± 12.8; p < 0.05). There was no response to dobutamine in dysfunctional segments with scar transmurality above 75% (n = 6): Ecc _endo (Rest: - 4.7 ± 3.0; 5 μg: - 2.9 ± 2.5; 10 μg: - 6.6 ± 3.3; p = ns), Ecc_epi (Rest: - 2.9 ± 2.9; 5 μg: - 5.4 ± 3.9; 10 μg: - 4.5 ± 4.2; p = ns) and Err (Rest:9.5 ± 5; 5 μg:5.4 ± 6.2; 10 μg:4.9 ± 3.3; p = ns). Circumferential strain (Ecc_endo, Ecc_epi) improved in all segments up to a transmurality of 75% (n = 60; p < 0.05). Err improved in segments < 50% transmurality (n = 45; p < 0.05) and remained unchanged above 50% transmurality (n = 21; p = ns). Conclusions: CMR-FT is a novel technique, which detects quantitative wall motion derived from SSFP cine imaging at rest and with low dose dobutamine stress. CMR-FT holds promise of quantitative assessment of viability in patients with ischemic cardiomyopathy.

Original language	English (US)
Pages (from-to)	413-420
Number of pages	8
Journal	International Journal of Cardiology
Volume	166
Issue number	2
DOIs	https://doi.org/10.1016/j.ijcard.2011.10.137
State	Published - Jun 20 2013
Externally published	Yes

Keywords

Cardiovascular magnetic resonance imaging
Hibernating myocardium
Myocardial feature tracking
Quantification
Viability

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.ijcard.2011.10.137

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Schuster, A., Paul, M., Bettencourt, N., Morton, G., Chiribiri, A., Ishida, M., Hussain, S., Jogiya, R., Kutty, S., Bigalke, B., Perera, D., & Nagel, E. (2013). Cardiovascular magnetic resonance myocardial feature tracking for quantitative viability assessment in ischemic cardiomyopathy. International Journal of Cardiology, 166(2), 413-420. https://doi.org/10.1016/j.ijcard.2011.10.137

Schuster, A, Paul, M, Bettencourt, N, Morton, G, Chiribiri, A, Ishida, M, Hussain, S, Jogiya, R, Kutty, S, Bigalke, B, Perera, D & Nagel, E 2013, 'Cardiovascular magnetic resonance myocardial feature tracking for quantitative viability assessment in ischemic cardiomyopathy', International Journal of Cardiology, vol. 166, no. 2, pp. 413-420. https://doi.org/10.1016/j.ijcard.2011.10.137

@article{9f6e968fd8334033939dfba23b1b563a,

title = "Cardiovascular magnetic resonance myocardial feature tracking for quantitative viability assessment in ischemic cardiomyopathy",

abstract = "Background: Low dose dobutamine stress magnetic resonance imaging is valuable to assess viability in patients with ischemic cardiomyopathy. Analysis is usually qualitative with considerable operator dependency. The aim of the current study was to investigate the feasibility of cine images derived quantitative cardiac magnetic resonance (CMR) myocardial feature tracking (FT) strain parameters to assess viability in patients with ischemic cardiomyopathy. Methods: 15 consecutive patients with ischemic cardiomyopathy referred for viability assessment were studied at 3 T at rest and during low dose dobutamine stress (5 and 10 μg/kg/min of dobutamine). Subendocardial and subepicardial circumferential (Eccendo and Eccepi) and radial (Err) strains were assessed using steady state free precession (SSFP) cine images orientated in 3 short axis slices covering 16 myocardial segments. Results: Dysfunctional segments without scar (n = 75) improved in all three strain parameters: Eccendo (Rest: - 10.5 ± 6.9; 5 μg: - 12.1 ± 6.9; 10 μg: - 14.1 ± 9.2; p < 0.05), Eccepi (Rest: - 7 ± 4.8; 5 μg: - 8.2 ± 5.5; 10 μg: - 9.1 ± 5.9; p < 0.05) and Err (Rest: 11.7 ± 8.3; 5 μg: 16 ± 10.9; 10 μg: 16.5 ± 12.8; p < 0.05). There was no response to dobutamine in dysfunctional segments with scar transmurality above 75% (n = 6): Ecc endo (Rest: - 4.7 ± 3.0; 5 μg: - 2.9 ± 2.5; 10 μg: - 6.6 ± 3.3; p = ns), Eccepi (Rest: - 2.9 ± 2.9; 5 μg: - 5.4 ± 3.9; 10 μg: - 4.5 ± 4.2; p = ns) and Err (Rest:9.5 ± 5; 5 μg:5.4 ± 6.2; 10 μg:4.9 ± 3.3; p = ns). Circumferential strain (Eccendo, Eccepi) improved in all segments up to a transmurality of 75% (n = 60; p < 0.05). Err improved in segments < 50% transmurality (n = 45; p < 0.05) and remained unchanged above 50% transmurality (n = 21; p = ns). Conclusions: CMR-FT is a novel technique, which detects quantitative wall motion derived from SSFP cine imaging at rest and with low dose dobutamine stress. CMR-FT holds promise of quantitative assessment of viability in patients with ischemic cardiomyopathy.",

keywords = "Cardiovascular magnetic resonance imaging, Hibernating myocardium, Myocardial feature tracking, Quantification, Viability",

author = "Andreas Schuster and Matthias Paul and Nuno Bettencourt and Geraint Morton and Amedeo Chiribiri and Masaki Ishida and Shazia Hussain and Roy Jogiya and Shelby Kutty and Boris Bigalke and Divaka Perera and Eike Nagel",

note = "Funding Information: Grant support: Andreas Schuster and Eike Nagel were supported by the British Heart Foundation (BHF) ( RE/08/003 and FS/10/029/28253 ) and the Biomedical Research Centre ( BRC-CTF 196 ). Eike Nagel received significant grant support from Bayer Schering Pharma and Philips Healthcare . Funding Information: Eike Nagel received minor consultancy fees from Philips Healthcare and major grant support from Philips Healthcare and Bayer Schering Pharma. The other authors declare that they have no competing interests. ",

year = "2013",

month = jun,

day = "20",

doi = "10.1016/j.ijcard.2011.10.137",

language = "English (US)",

volume = "166",

pages = "413--420",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Cardiovascular magnetic resonance myocardial feature tracking for quantitative viability assessment in ischemic cardiomyopathy

AU - Schuster, Andreas

AU - Paul, Matthias

AU - Bettencourt, Nuno

AU - Morton, Geraint

AU - Chiribiri, Amedeo

AU - Ishida, Masaki

AU - Hussain, Shazia

AU - Jogiya, Roy

AU - Kutty, Shelby

AU - Bigalke, Boris

AU - Perera, Divaka

AU - Nagel, Eike

N1 - Funding Information: Grant support: Andreas Schuster and Eike Nagel were supported by the British Heart Foundation (BHF) ( RE/08/003 and FS/10/029/28253 ) and the Biomedical Research Centre ( BRC-CTF 196 ). Eike Nagel received significant grant support from Bayer Schering Pharma and Philips Healthcare . Funding Information: Eike Nagel received minor consultancy fees from Philips Healthcare and major grant support from Philips Healthcare and Bayer Schering Pharma. The other authors declare that they have no competing interests.

PY - 2013/6/20

Y1 - 2013/6/20

N2 - Background: Low dose dobutamine stress magnetic resonance imaging is valuable to assess viability in patients with ischemic cardiomyopathy. Analysis is usually qualitative with considerable operator dependency. The aim of the current study was to investigate the feasibility of cine images derived quantitative cardiac magnetic resonance (CMR) myocardial feature tracking (FT) strain parameters to assess viability in patients with ischemic cardiomyopathy. Methods: 15 consecutive patients with ischemic cardiomyopathy referred for viability assessment were studied at 3 T at rest and during low dose dobutamine stress (5 and 10 μg/kg/min of dobutamine). Subendocardial and subepicardial circumferential (Eccendo and Eccepi) and radial (Err) strains were assessed using steady state free precession (SSFP) cine images orientated in 3 short axis slices covering 16 myocardial segments. Results: Dysfunctional segments without scar (n = 75) improved in all three strain parameters: Eccendo (Rest: - 10.5 ± 6.9; 5 μg: - 12.1 ± 6.9; 10 μg: - 14.1 ± 9.2; p < 0.05), Eccepi (Rest: - 7 ± 4.8; 5 μg: - 8.2 ± 5.5; 10 μg: - 9.1 ± 5.9; p < 0.05) and Err (Rest: 11.7 ± 8.3; 5 μg: 16 ± 10.9; 10 μg: 16.5 ± 12.8; p < 0.05). There was no response to dobutamine in dysfunctional segments with scar transmurality above 75% (n = 6): Ecc endo (Rest: - 4.7 ± 3.0; 5 μg: - 2.9 ± 2.5; 10 μg: - 6.6 ± 3.3; p = ns), Eccepi (Rest: - 2.9 ± 2.9; 5 μg: - 5.4 ± 3.9; 10 μg: - 4.5 ± 4.2; p = ns) and Err (Rest:9.5 ± 5; 5 μg:5.4 ± 6.2; 10 μg:4.9 ± 3.3; p = ns). Circumferential strain (Eccendo, Eccepi) improved in all segments up to a transmurality of 75% (n = 60; p < 0.05). Err improved in segments < 50% transmurality (n = 45; p < 0.05) and remained unchanged above 50% transmurality (n = 21; p = ns). Conclusions: CMR-FT is a novel technique, which detects quantitative wall motion derived from SSFP cine imaging at rest and with low dose dobutamine stress. CMR-FT holds promise of quantitative assessment of viability in patients with ischemic cardiomyopathy.

AB - Background: Low dose dobutamine stress magnetic resonance imaging is valuable to assess viability in patients with ischemic cardiomyopathy. Analysis is usually qualitative with considerable operator dependency. The aim of the current study was to investigate the feasibility of cine images derived quantitative cardiac magnetic resonance (CMR) myocardial feature tracking (FT) strain parameters to assess viability in patients with ischemic cardiomyopathy. Methods: 15 consecutive patients with ischemic cardiomyopathy referred for viability assessment were studied at 3 T at rest and during low dose dobutamine stress (5 and 10 μg/kg/min of dobutamine). Subendocardial and subepicardial circumferential (Eccendo and Eccepi) and radial (Err) strains were assessed using steady state free precession (SSFP) cine images orientated in 3 short axis slices covering 16 myocardial segments. Results: Dysfunctional segments without scar (n = 75) improved in all three strain parameters: Eccendo (Rest: - 10.5 ± 6.9; 5 μg: - 12.1 ± 6.9; 10 μg: - 14.1 ± 9.2; p < 0.05), Eccepi (Rest: - 7 ± 4.8; 5 μg: - 8.2 ± 5.5; 10 μg: - 9.1 ± 5.9; p < 0.05) and Err (Rest: 11.7 ± 8.3; 5 μg: 16 ± 10.9; 10 μg: 16.5 ± 12.8; p < 0.05). There was no response to dobutamine in dysfunctional segments with scar transmurality above 75% (n = 6): Ecc endo (Rest: - 4.7 ± 3.0; 5 μg: - 2.9 ± 2.5; 10 μg: - 6.6 ± 3.3; p = ns), Eccepi (Rest: - 2.9 ± 2.9; 5 μg: - 5.4 ± 3.9; 10 μg: - 4.5 ± 4.2; p = ns) and Err (Rest:9.5 ± 5; 5 μg:5.4 ± 6.2; 10 μg:4.9 ± 3.3; p = ns). Circumferential strain (Eccendo, Eccepi) improved in all segments up to a transmurality of 75% (n = 60; p < 0.05). Err improved in segments < 50% transmurality (n = 45; p < 0.05) and remained unchanged above 50% transmurality (n = 21; p = ns). Conclusions: CMR-FT is a novel technique, which detects quantitative wall motion derived from SSFP cine imaging at rest and with low dose dobutamine stress. CMR-FT holds promise of quantitative assessment of viability in patients with ischemic cardiomyopathy.

KW - Cardiovascular magnetic resonance imaging

KW - Hibernating myocardium

KW - Myocardial feature tracking

KW - Quantification

KW - Viability

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Cardiovascular magnetic resonance myocardial feature tracking for quantitative viability assessment in ischemic cardiomyopathy

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