Cardiovascular Magnetic Resonance for Patients With COVID-19

Steffen E. Petersen; Matthias G. Friedrich; Tim Leiner; Matthew D. Elias; Vanessa M. Ferreira; Maximilian Fenski; Scott D. Flamm; Mark Fogel; Ria Garg; Marc K. Halushka; Allison G. Hays; Nadine Kawel-Boehm; Christopher M. Kramer; Eike Nagel; Ntobeko A.B. Ntusi; Ellen Ostenfeld; Dudley J. Pennell; Zahra Raisi-Estabragh; Scott B. Reeder; Carlos E. Rochitte; Jitka Starekova; Dominika Suchá; Qian Tao; Jeanette Schulz-Menger; David A. Bluemke

doi:10.1016/j.jcmg.2021.08.021

Cardiovascular Magnetic Resonance for Patients With COVID-19

Steffen E. Petersen, Matthias G. Friedrich, Tim Leiner, Matthew D. Elias, Vanessa M. Ferreira, Maximilian Fenski, Scott D. Flamm, Mark Fogel, Ria Garg, Marc K. Halushka, Allison G. Hays, Nadine Kawel-Boehm, Christopher M. Kramer, Eike Nagel, Ntobeko A.B. Ntusi, Ellen Ostenfeld, Dudley J. Pennell, Zahra Raisi-Estabragh, Scott B. Reeder, Carlos E. RochitteJitka Starekova, Dominika Suchá, Qian Tao, Jeanette Schulz-Menger, David A. Bluemke

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

COVID-19 is associated with myocardial injury caused by ischemia, inflammation, or myocarditis. Cardiovascular magnetic resonance (CMR) is the noninvasive reference standard for cardiac function, structure, and tissue composition. CMR is a potentially valuable diagnostic tool in patients with COVID-19 presenting with myocardial injury and evidence of cardiac dysfunction. Although COVID-19–related myocarditis is likely infrequent, COVID-19–related cardiovascular histopathology findings have been reported in up to 48% of patients, raising the concern for long-term myocardial injury. Studies to date report CMR abnormalities in 26% to 60% of hospitalized patients who have recovered from COVID-19, including functional impairment, myocardial tissue abnormalities, late gadolinium enhancement, or pericardial abnormalities. In athletes post–COVID-19, CMR has detected myocarditis-like abnormalities. In children, multisystem inflammatory syndrome may occur 2 to 6 weeks after infection; associated myocarditis and coronary artery aneurysms are evaluable by CMR. At this time, our understanding of COVID-19–related cardiovascular involvement is incomplete, and multiple studies are planned to evaluate patients with COVID-19 using CMR. In this review, we summarize existing studies of CMR for patients with COVID-19 and present ongoing research. We also provide recommendations for clinical use of CMR for patients with acute symptoms or who are recovering from COVID-19.

Original language	English (US)
Pages (from-to)	685-699
Number of pages	15
Journal	JACC: Cardiovascular Imaging
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/j.jcmg.2021.08.021
State	Published - Apr 2022

Keywords

COVID-19
SARS-CoV-2
cardiovascular magnetic resonance
ischemia
multisystem inflammatory syndrome
myocardial injury
myocarditis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Radiology Nuclear Medicine and imaging

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10.1016/j.jcmg.2021.08.021

Cite this

Petersen, S. E., Friedrich, M. G., Leiner, T., Elias, M. D., Ferreira, V. M., Fenski, M., Flamm, S. D., Fogel, M., Garg, R., Halushka, M. K., Hays, A. G., Kawel-Boehm, N., Kramer, C. M., Nagel, E., Ntusi, N. A. B., Ostenfeld, E., Pennell, D. J., Raisi-Estabragh, Z., Reeder, S. B., ... Bluemke, D. A. (2022). Cardiovascular Magnetic Resonance for Patients With COVID-19. JACC: Cardiovascular Imaging, 15(4), 685-699. https://doi.org/10.1016/j.jcmg.2021.08.021

Petersen, SE, Friedrich, MG, Leiner, T, Elias, MD, Ferreira, VM, Fenski, M, Flamm, SD, Fogel, M, Garg, R, Halushka, MK, Hays, AG, Kawel-Boehm, N, Kramer, CM, Nagel, E, Ntusi, NAB, Ostenfeld, E, Pennell, DJ, Raisi-Estabragh, Z, Reeder, SB, Rochitte, CE, Starekova, J, Suchá, D, Tao, Q, Schulz-Menger, J & Bluemke, DA 2022, 'Cardiovascular Magnetic Resonance for Patients With COVID-19', JACC: Cardiovascular Imaging, vol. 15, no. 4, pp. 685-699. https://doi.org/10.1016/j.jcmg.2021.08.021

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title = "Cardiovascular Magnetic Resonance for Patients With COVID-19",

abstract = "COVID-19 is associated with myocardial injury caused by ischemia, inflammation, or myocarditis. Cardiovascular magnetic resonance (CMR) is the noninvasive reference standard for cardiac function, structure, and tissue composition. CMR is a potentially valuable diagnostic tool in patients with COVID-19 presenting with myocardial injury and evidence of cardiac dysfunction. Although COVID-19–related myocarditis is likely infrequent, COVID-19–related cardiovascular histopathology findings have been reported in up to 48% of patients, raising the concern for long-term myocardial injury. Studies to date report CMR abnormalities in 26% to 60% of hospitalized patients who have recovered from COVID-19, including functional impairment, myocardial tissue abnormalities, late gadolinium enhancement, or pericardial abnormalities. In athletes post–COVID-19, CMR has detected myocarditis-like abnormalities. In children, multisystem inflammatory syndrome may occur 2 to 6 weeks after infection; associated myocarditis and coronary artery aneurysms are evaluable by CMR. At this time, our understanding of COVID-19–related cardiovascular involvement is incomplete, and multiple studies are planned to evaluate patients with COVID-19 using CMR. In this review, we summarize existing studies of CMR for patients with COVID-19 and present ongoing research. We also provide recommendations for clinical use of CMR for patients with acute symptoms or who are recovering from COVID-19.",

keywords = "COVID-19, SARS-CoV-2, cardiovascular magnetic resonance, ischemia, multisystem inflammatory syndrome, myocardial injury, myocarditis",

author = "Petersen, {Steffen E.} and Friedrich, {Matthias G.} and Tim Leiner and Elias, {Matthew D.} and Ferreira, {Vanessa M.} and Maximilian Fenski and Flamm, {Scott D.} and Mark Fogel and Ria Garg and Halushka, {Marc K.} and Hays, {Allison G.} and Nadine Kawel-Boehm and Kramer, {Christopher M.} and Eike Nagel and Ntusi, {Ntobeko A.B.} and Ellen Ostenfeld and Pennell, {Dudley J.} and Zahra Raisi-Estabragh and Reeder, {Scott B.} and Rochitte, {Carlos E.} and Jitka Starekova and Dominika Such{\'a} and Qian Tao and Jeanette Schulz-Menger and Bluemke, {David A.}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = apr,

doi = "10.1016/j.jcmg.2021.08.021",

language = "English (US)",

volume = "15",

pages = "685--699",

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T1 - Cardiovascular Magnetic Resonance for Patients With COVID-19

AU - Petersen, Steffen E.

AU - Friedrich, Matthias G.

AU - Leiner, Tim

AU - Elias, Matthew D.

AU - Ferreira, Vanessa M.

AU - Fenski, Maximilian

AU - Flamm, Scott D.

AU - Fogel, Mark

AU - Garg, Ria

AU - Halushka, Marc K.

AU - Hays, Allison G.

AU - Kawel-Boehm, Nadine

AU - Kramer, Christopher M.

AU - Nagel, Eike

AU - Ntusi, Ntobeko A.B.

AU - Ostenfeld, Ellen

AU - Pennell, Dudley J.

AU - Raisi-Estabragh, Zahra

AU - Reeder, Scott B.

AU - Rochitte, Carlos E.

AU - Starekova, Jitka

AU - Suchá, Dominika

AU - Tao, Qian

AU - Schulz-Menger, Jeanette

AU - Bluemke, David A.

PY - 2022/4

Y1 - 2022/4

N2 - COVID-19 is associated with myocardial injury caused by ischemia, inflammation, or myocarditis. Cardiovascular magnetic resonance (CMR) is the noninvasive reference standard for cardiac function, structure, and tissue composition. CMR is a potentially valuable diagnostic tool in patients with COVID-19 presenting with myocardial injury and evidence of cardiac dysfunction. Although COVID-19–related myocarditis is likely infrequent, COVID-19–related cardiovascular histopathology findings have been reported in up to 48% of patients, raising the concern for long-term myocardial injury. Studies to date report CMR abnormalities in 26% to 60% of hospitalized patients who have recovered from COVID-19, including functional impairment, myocardial tissue abnormalities, late gadolinium enhancement, or pericardial abnormalities. In athletes post–COVID-19, CMR has detected myocarditis-like abnormalities. In children, multisystem inflammatory syndrome may occur 2 to 6 weeks after infection; associated myocarditis and coronary artery aneurysms are evaluable by CMR. At this time, our understanding of COVID-19–related cardiovascular involvement is incomplete, and multiple studies are planned to evaluate patients with COVID-19 using CMR. In this review, we summarize existing studies of CMR for patients with COVID-19 and present ongoing research. We also provide recommendations for clinical use of CMR for patients with acute symptoms or who are recovering from COVID-19.

AB - COVID-19 is associated with myocardial injury caused by ischemia, inflammation, or myocarditis. Cardiovascular magnetic resonance (CMR) is the noninvasive reference standard for cardiac function, structure, and tissue composition. CMR is a potentially valuable diagnostic tool in patients with COVID-19 presenting with myocardial injury and evidence of cardiac dysfunction. Although COVID-19–related myocarditis is likely infrequent, COVID-19–related cardiovascular histopathology findings have been reported in up to 48% of patients, raising the concern for long-term myocardial injury. Studies to date report CMR abnormalities in 26% to 60% of hospitalized patients who have recovered from COVID-19, including functional impairment, myocardial tissue abnormalities, late gadolinium enhancement, or pericardial abnormalities. In athletes post–COVID-19, CMR has detected myocarditis-like abnormalities. In children, multisystem inflammatory syndrome may occur 2 to 6 weeks after infection; associated myocarditis and coronary artery aneurysms are evaluable by CMR. At this time, our understanding of COVID-19–related cardiovascular involvement is incomplete, and multiple studies are planned to evaluate patients with COVID-19 using CMR. In this review, we summarize existing studies of CMR for patients with COVID-19 and present ongoing research. We also provide recommendations for clinical use of CMR for patients with acute symptoms or who are recovering from COVID-19.

KW - COVID-19

KW - SARS-CoV-2

KW - cardiovascular magnetic resonance

KW - ischemia

KW - multisystem inflammatory syndrome

KW - myocardial injury

KW - myocarditis

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U2 - 10.1016/j.jcmg.2021.08.021

DO - 10.1016/j.jcmg.2021.08.021

M3 - Review article

C2 - 34656482

AN - SCOPUS:85123513653

SN - 1936-878X

VL - 15

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JO - JACC: Cardiovascular Imaging

JF - JACC: Cardiovascular Imaging

IS - 4

ER -

Cardiovascular Magnetic Resonance for Patients With COVID-19

Abstract

Keywords

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