TY - JOUR
T1 - Cardiovascular function in multi-ethnic study of atherosclerosis
T2 - Normal values by age, sex, and ethnicity
AU - Natori, Shunsuke
AU - Lai, Shenghan
AU - Finn, J. Paul
AU - Gomes, Antoinette S.
AU - Hundley, W. Gregory
AU - Jerosch-Herold, Michael
AU - Pearson, Gregory
AU - Sinha, Shantanu
AU - Arai, Andrew
AU - Lima, Joao A.C.
AU - Bluemke, David A.
PY - 2006/6
Y1 - 2006/6
N2 - OBJECTIVE. MRI provides accurate and high-resolution measurements of cardiac anatomy and function. The purpose of this study was to describe the imaging protocol and normal values of left ventricular (LV) function and mass in the Multi-Ethnic Study of Atherosclerosis (MESA). SUBJECTS AND METHODS. Eight hundred participants (400 men, 400 women) in four age strata (45-54, 55-64, 65-74, 75-84 years) were chosen at random. Participants with the following known cardiovascular risk factors were excluded: current smoker, systolic blood pressure > 140 mm Hg, diastolic blood pressure > 90 mm Hg, fasting glucose > 110 mg/dL, total cholesterol > 240 mg/dL, and high-density lipoprotein (HDL) cholesterol < 40 mg/dL. Cardiac MR images were analyzed using MASS software (version 4.2). Mean values, SDs, and correlation coefficients in relationship to patient age were calculated. RESULTS. There were significant differences in LV volumes and mass between men and women. LV volumes were inversely associated with age (p < 0.05) for both sexes except for the LV end-systolic volume index. For men, LV mass was inversely associated with age (slope = -0.72 g/year, p = 0.0021), but LV mass index was not associated with age (slope = -0.179 g/m2/year, p = 0.075). For women, LV mass (slope = -0.15 g/year, p = 0.30) and LV mass index (slope = 0.0044 g/m 2/year, p = 0.95) were not associated with age. LV mass was the largest in the African-American group (men, 181.6 ± 35.8 [SD] g; women, 128.8 ± 28.1 g) and was smallest in the Asian-American group (men, 129.1 ± 20.0 g; women, 89.4 ± 13.3 g). CONCLUSION. The normal LV differs in volume and mass between sexes and among certain ethnic groups. When indexed by body surface area, LV mass was independent of age for both sexes. Studies that assess cardiovascular risk factors in relationship to cardiac function and structure need to account for these normal variations in the population.
AB - OBJECTIVE. MRI provides accurate and high-resolution measurements of cardiac anatomy and function. The purpose of this study was to describe the imaging protocol and normal values of left ventricular (LV) function and mass in the Multi-Ethnic Study of Atherosclerosis (MESA). SUBJECTS AND METHODS. Eight hundred participants (400 men, 400 women) in four age strata (45-54, 55-64, 65-74, 75-84 years) were chosen at random. Participants with the following known cardiovascular risk factors were excluded: current smoker, systolic blood pressure > 140 mm Hg, diastolic blood pressure > 90 mm Hg, fasting glucose > 110 mg/dL, total cholesterol > 240 mg/dL, and high-density lipoprotein (HDL) cholesterol < 40 mg/dL. Cardiac MR images were analyzed using MASS software (version 4.2). Mean values, SDs, and correlation coefficients in relationship to patient age were calculated. RESULTS. There were significant differences in LV volumes and mass between men and women. LV volumes were inversely associated with age (p < 0.05) for both sexes except for the LV end-systolic volume index. For men, LV mass was inversely associated with age (slope = -0.72 g/year, p = 0.0021), but LV mass index was not associated with age (slope = -0.179 g/m2/year, p = 0.075). For women, LV mass (slope = -0.15 g/year, p = 0.30) and LV mass index (slope = 0.0044 g/m 2/year, p = 0.95) were not associated with age. LV mass was the largest in the African-American group (men, 181.6 ± 35.8 [SD] g; women, 128.8 ± 28.1 g) and was smallest in the Asian-American group (men, 129.1 ± 20.0 g; women, 89.4 ± 13.3 g). CONCLUSION. The normal LV differs in volume and mass between sexes and among certain ethnic groups. When indexed by body surface area, LV mass was independent of age for both sexes. Studies that assess cardiovascular risk factors in relationship to cardiac function and structure need to account for these normal variations in the population.
KW - Atherosclerosis
KW - Cardiac function
KW - Cardiac imaging
KW - Ejection fraction
KW - Heart
KW - Left ventricle
KW - Left ventricle mass
KW - MRI
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U2 - 10.2214/AJR.04.1868
DO - 10.2214/AJR.04.1868
M3 - Article
C2 - 16714609
AN - SCOPUS:33745541684
SN - 0361-803X
VL - 186
SP - S357-S365
JO - American Journal of Roentgenology
JF - American Journal of Roentgenology
IS - 6 SUPPL. A
ER -