Cardiovascular function in multi-ethnic study of atherosclerosis

Normal values by age, sex, and ethnicity

Shunsuke Natori, Shenghan Lai, J. Paul Finn, Antoinette S. Gomes, W. Gregory Hundley, Michael Jerosch-Herold, Gregory Pearson, Shantanu Sinha, Andrew Arai, Joao Lima, David A. Bluemke

Research output: Contribution to journalArticle

Abstract

OBJECTIVE. MRI provides accurate and high-resolution measurements of cardiac anatomy and function. The purpose of this study was to describe the imaging protocol and normal values of left ventricular (LV) function and mass in the Multi-Ethnic Study of Atherosclerosis (MESA). SUBJECTS AND METHODS. Eight hundred participants (400 men, 400 women) in four age strata (45-54, 55-64, 65-74, 75-84 years) were chosen at random. Participants with the following known cardiovascular risk factors were excluded: current smoker, systolic blood pressure > 140 mm Hg, diastolic blood pressure > 90 mm Hg, fasting glucose > 110 mg/dL, total cholesterol > 240 mg/dL, and high-density lipoprotein (HDL) cholesterol <40 mg/dL. Cardiac MR images were analyzed using MASS software (version 4.2). Mean values, SDs, and correlation coefficients in relationship to patient age were calculated. RESULTS. There were significant differences in LV volumes and mass between men and women. LV volumes were inversely associated with age (p <0.05) for both sexes except for the LV end-systolic volume index. For men, LV mass was inversely associated with age (slope = -0.72 g/year, p = 0.0021), but LV mass index was not associated with age (slope = -0.179 g/m2/year, p = 0.075). For women, LV mass (slope = -0.15 g/year, p = 0.30) and LV mass index (slope = 0.0044 g/m 2/year, p = 0.95) were not associated with age. LV mass was the largest in the African-American group (men, 181.6 ± 35.8 [SD] g; women, 128.8 ± 28.1 g) and was smallest in the Asian-American group (men, 129.1 ± 20.0 g; women, 89.4 ± 13.3 g). CONCLUSION. The normal LV differs in volume and mass between sexes and among certain ethnic groups. When indexed by body surface area, LV mass was independent of age for both sexes. Studies that assess cardiovascular risk factors in relationship to cardiac function and structure need to account for these normal variations in the population.

Original languageEnglish (US)
JournalAmerican Journal of Roentgenology
Volume186
Issue number6 SUPPL. A
DOIs
StatePublished - Jun 2006

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Atherosclerosis
Reference Values
Blood Pressure
Asian Americans
Body Surface Area
Left Ventricular Function
Ethnic Groups
African Americans
Stroke Volume
HDL Cholesterol
Fasting
Anatomy
Software
Cholesterol
Glucose
Population

Keywords

  • Atherosclerosis
  • Cardiac function
  • Cardiac imaging
  • Ejection fraction
  • Heart
  • Left ventricle
  • Left ventricle mass
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Natori, S., Lai, S., Finn, J. P., Gomes, A. S., Hundley, W. G., Jerosch-Herold, M., ... Bluemke, D. A. (2006). Cardiovascular function in multi-ethnic study of atherosclerosis: Normal values by age, sex, and ethnicity. American Journal of Roentgenology, 186(6 SUPPL. A). https://doi.org/10.2214/AJR.04.1868

Cardiovascular function in multi-ethnic study of atherosclerosis : Normal values by age, sex, and ethnicity. / Natori, Shunsuke; Lai, Shenghan; Finn, J. Paul; Gomes, Antoinette S.; Hundley, W. Gregory; Jerosch-Herold, Michael; Pearson, Gregory; Sinha, Shantanu; Arai, Andrew; Lima, Joao; Bluemke, David A.

In: American Journal of Roentgenology, Vol. 186, No. 6 SUPPL. A, 06.2006.

Research output: Contribution to journalArticle

Natori, S, Lai, S, Finn, JP, Gomes, AS, Hundley, WG, Jerosch-Herold, M, Pearson, G, Sinha, S, Arai, A, Lima, J & Bluemke, DA 2006, 'Cardiovascular function in multi-ethnic study of atherosclerosis: Normal values by age, sex, and ethnicity', American Journal of Roentgenology, vol. 186, no. 6 SUPPL. A. https://doi.org/10.2214/AJR.04.1868
Natori, Shunsuke ; Lai, Shenghan ; Finn, J. Paul ; Gomes, Antoinette S. ; Hundley, W. Gregory ; Jerosch-Herold, Michael ; Pearson, Gregory ; Sinha, Shantanu ; Arai, Andrew ; Lima, Joao ; Bluemke, David A. / Cardiovascular function in multi-ethnic study of atherosclerosis : Normal values by age, sex, and ethnicity. In: American Journal of Roentgenology. 2006 ; Vol. 186, No. 6 SUPPL. A.
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AU - Gomes, Antoinette S.

AU - Hundley, W. Gregory

AU - Jerosch-Herold, Michael

AU - Pearson, Gregory

AU - Sinha, Shantanu

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AU - Lima, Joao

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N2 - OBJECTIVE. MRI provides accurate and high-resolution measurements of cardiac anatomy and function. The purpose of this study was to describe the imaging protocol and normal values of left ventricular (LV) function and mass in the Multi-Ethnic Study of Atherosclerosis (MESA). SUBJECTS AND METHODS. Eight hundred participants (400 men, 400 women) in four age strata (45-54, 55-64, 65-74, 75-84 years) were chosen at random. Participants with the following known cardiovascular risk factors were excluded: current smoker, systolic blood pressure > 140 mm Hg, diastolic blood pressure > 90 mm Hg, fasting glucose > 110 mg/dL, total cholesterol > 240 mg/dL, and high-density lipoprotein (HDL) cholesterol <40 mg/dL. Cardiac MR images were analyzed using MASS software (version 4.2). Mean values, SDs, and correlation coefficients in relationship to patient age were calculated. RESULTS. There were significant differences in LV volumes and mass between men and women. LV volumes were inversely associated with age (p <0.05) for both sexes except for the LV end-systolic volume index. For men, LV mass was inversely associated with age (slope = -0.72 g/year, p = 0.0021), but LV mass index was not associated with age (slope = -0.179 g/m2/year, p = 0.075). For women, LV mass (slope = -0.15 g/year, p = 0.30) and LV mass index (slope = 0.0044 g/m 2/year, p = 0.95) were not associated with age. LV mass was the largest in the African-American group (men, 181.6 ± 35.8 [SD] g; women, 128.8 ± 28.1 g) and was smallest in the Asian-American group (men, 129.1 ± 20.0 g; women, 89.4 ± 13.3 g). CONCLUSION. The normal LV differs in volume and mass between sexes and among certain ethnic groups. When indexed by body surface area, LV mass was independent of age for both sexes. Studies that assess cardiovascular risk factors in relationship to cardiac function and structure need to account for these normal variations in the population.

AB - OBJECTIVE. MRI provides accurate and high-resolution measurements of cardiac anatomy and function. The purpose of this study was to describe the imaging protocol and normal values of left ventricular (LV) function and mass in the Multi-Ethnic Study of Atherosclerosis (MESA). SUBJECTS AND METHODS. Eight hundred participants (400 men, 400 women) in four age strata (45-54, 55-64, 65-74, 75-84 years) were chosen at random. Participants with the following known cardiovascular risk factors were excluded: current smoker, systolic blood pressure > 140 mm Hg, diastolic blood pressure > 90 mm Hg, fasting glucose > 110 mg/dL, total cholesterol > 240 mg/dL, and high-density lipoprotein (HDL) cholesterol <40 mg/dL. Cardiac MR images were analyzed using MASS software (version 4.2). Mean values, SDs, and correlation coefficients in relationship to patient age were calculated. RESULTS. There were significant differences in LV volumes and mass between men and women. LV volumes were inversely associated with age (p <0.05) for both sexes except for the LV end-systolic volume index. For men, LV mass was inversely associated with age (slope = -0.72 g/year, p = 0.0021), but LV mass index was not associated with age (slope = -0.179 g/m2/year, p = 0.075). For women, LV mass (slope = -0.15 g/year, p = 0.30) and LV mass index (slope = 0.0044 g/m 2/year, p = 0.95) were not associated with age. LV mass was the largest in the African-American group (men, 181.6 ± 35.8 [SD] g; women, 128.8 ± 28.1 g) and was smallest in the Asian-American group (men, 129.1 ± 20.0 g; women, 89.4 ± 13.3 g). CONCLUSION. The normal LV differs in volume and mass between sexes and among certain ethnic groups. When indexed by body surface area, LV mass was independent of age for both sexes. Studies that assess cardiovascular risk factors in relationship to cardiac function and structure need to account for these normal variations in the population.

KW - Atherosclerosis

KW - Cardiac function

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KW - Ejection fraction

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