Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat

Peter D. Feldman, Nibras Parveen, Sena Sezen

Research output: Contribution to journalArticle


Microinjections of Leu-enkephalin into the dorsal vagal complex induced hypotension and bradycardia. Both naloxone, given at a dose conferring selectivity for μ receptors, and the δ antagonist ICI 154,129 prevented the cardiovascular effects of Leu-enkephalin. Naloxone was also found to decrease the gain of the baroreflex. These results suggest that Leu-enkephalin is involved in cardiovascular regulation through activation of δ-, and possibly μ-, opioid receptors in the dorsal vagal complex.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalBrain Research
Issue number2
Publication statusPublished - Feb 19 1996
Externally publishedYes



  • δ
  • μ
  • Autonomic
  • Enkephalin
  • ICI 154,129
  • Naloxone
  • Opioid
  • Solitarius
  • Vagal

ASJC Scopus subject areas

  • Neuroscience(all)

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