Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat

Peter D. Feldman, Nibras Parveen, Sena Sezen

Research output: Contribution to journalArticle

Abstract

Microinjections of Leu-enkephalin into the dorsal vagal complex induced hypotension and bradycardia. Both naloxone, given at a dose conferring selectivity for μ receptors, and the δ antagonist ICI 154,129 prevented the cardiovascular effects of Leu-enkephalin. Naloxone was also found to decrease the gain of the baroreflex. These results suggest that Leu-enkephalin is involved in cardiovascular regulation through activation of δ-, and possibly μ-, opioid receptors in the dorsal vagal complex.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalBrain Research
Volume709
Issue number2
DOIs
StatePublished - Feb 19 1996
Externally publishedYes

Fingerprint

Leucine Enkephalin
Solitary Nucleus
Naloxone
Controlled Hypotension
Baroreflex
Microinjections
Opioid Receptors
Bradycardia

Keywords

  • δ
  • μ
  • Autonomic
  • Enkephalin
  • ICI 154,129
  • Naloxone
  • Opioid
  • Solitarius
  • Vagal

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat. / Feldman, Peter D.; Parveen, Nibras; Sezen, Sena.

In: Brain Research, Vol. 709, No. 2, 19.02.1996, p. 331-336.

Research output: Contribution to journalArticle

Feldman, Peter D. ; Parveen, Nibras ; Sezen, Sena. / Cardiovascular effects of Leu-enkephalin in the nucleus tractus solitarius of the rat. In: Brain Research. 1996 ; Vol. 709, No. 2. pp. 331-336.
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