Cardiovascular effects of colforsin daropate hydrochloride for acute heart failure after open heart surgery

Narutoshi Hibino, A. Kawai, S. Uchikawa, G. Chikazawa, T. Kurihara, S. Kihara, K. Uebe, S. Aomi, H. Nishida, M. Endo, H. Koyanagi

Research output: Contribution to journalArticlepeer-review

Abstract

Colforsin daropate hydrochloride (COL) is a novel drug for the treatment of acute heart failure. COL stimulates adenylate cyclase directly and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP. We investigated its cardiovascular effects for 9 patients who showed low cardiac index (< 3.0 l/min/m2) after open-heart surgery in ICU. After 2 or 3 hours from administration of COL, heart rate and cardiac index increased, and pulmonary artery pressure and central venous pressure decreased significantly, but blood pressure and systemic venous oxygen saturation did not show significant change. In conclusion, COL improved hemodynamics through positive inotropic and vasodilator effects without hypotension. We should investigate more proper usage of this drug to avoid such side effects as tachycardia and arrhythmia, which occurred in some cases.

Original languageEnglish (US)
Pages (from-to)1016-1019
Number of pages4
JournalKyobu geka. The Japanese journal of thoracic surgery
Volume54
Issue number12
StatePublished - 2001
Externally publishedYes

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