Abstract
Cardiovascular diseases are the leading cause of death for population over 65 years of age. With the progressive increase of population in this age group, it is crucial to understand the interaction between aging and cardiovascular diseases. Aging results in structural changes and functional decline of the cardiovascular system and is a major risk factor for cardiovascular diseases. Aging not only increases the prevalence of cardiovascular diseases but is also associated with impaired responses to cardiovascular diseases. This supports the notion that age-related changes in the cardiovascular system superimpose and interact with the pathophysiological mechanisms that lead to cardiovascular disease. This chapter will provide an overview of cardiovascular aging in humans and mammalian models, and discuss the recent advances in understanding how different hallmarks of aging play their roles in the pathogenesis of cardiovascular aging.
| Original language | English (US) |
|---|---|
| Title of host publication | Advances in Geroscience |
| Publisher | Springer International Publishing |
| Pages | 121-160 |
| Number of pages | 40 |
| ISBN (Electronic) | 9783319232461 |
| ISBN (Print) | 9783319232454 |
| DOIs | |
| State | Published - Jan 1 2015 |
Keywords
- Angiogenesis
- Arterial aging
- Cardiovascular reserve
- Geroscience
- Heart aging
- Vascular aging
ASJC Scopus subject areas
- General Medicine
- General Biochemistry, Genetics and Molecular Biology
- General Social Sciences
- General Psychology