Cardiovascular changes with aging

The response to exercise

Research output: Contribution to journalArticle

Abstract

There are several cardiovascular parameters that change with the normal aging process in both animal models and man, which may affect the response to exercise. Although the aging process is associated with normal resting contractile function, diastolic properties are altered resulting in reduced and delayed early left ventricular filling and an enhanced atrial contribution to end diastolic volume. Exercise cardiact output is maintained in healthy elderly individuals, however, there is a shift from reliance on an increase in heart rate and decrease in end systolic volume to use of the Frank-Starling mechanism to increase stroke volume. This age difference in the cardiovascular response to exercise is probably mediated by an age associated decreased responsiveness to beta-adrenergic stimulation.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalJournal of Cardiopulmonary Rehabilitation
Volume9
Issue number1
StatePublished - 1989

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Exercise
Starlings
Stroke Volume
Adrenergic Agents
Animal Models
Heart Rate

ASJC Scopus subject areas

  • Rehabilitation

Cite this

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abstract = "There are several cardiovascular parameters that change with the normal aging process in both animal models and man, which may affect the response to exercise. Although the aging process is associated with normal resting contractile function, diastolic properties are altered resulting in reduced and delayed early left ventricular filling and an enhanced atrial contribution to end diastolic volume. Exercise cardiact output is maintained in healthy elderly individuals, however, there is a shift from reliance on an increase in heart rate and decrease in end systolic volume to use of the Frank-Starling mechanism to increase stroke volume. This age difference in the cardiovascular response to exercise is probably mediated by an age associated decreased responsiveness to beta-adrenergic stimulation.",
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AB - There are several cardiovascular parameters that change with the normal aging process in both animal models and man, which may affect the response to exercise. Although the aging process is associated with normal resting contractile function, diastolic properties are altered resulting in reduced and delayed early left ventricular filling and an enhanced atrial contribution to end diastolic volume. Exercise cardiact output is maintained in healthy elderly individuals, however, there is a shift from reliance on an increase in heart rate and decrease in end systolic volume to use of the Frank-Starling mechanism to increase stroke volume. This age difference in the cardiovascular response to exercise is probably mediated by an age associated decreased responsiveness to beta-adrenergic stimulation.

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