Cardiovascular changes in response to selective monoamine oxidase inhibition in the rat

Robert M. Cohen, Iain C. Campbell, Isamu Yamaguchi, David Pickar, Irwin J. Kopin, Dennis L. Murphy

Research output: Contribution to journalArticle

Abstract

Chronic (21 days) treatment with the selective monoamine oxidase (MAO)-A inhibitor clorgyline, but not with the MAO-B inhibitor deprenyl in pithed rats leads to increased blood pressure responses to sympathetic stimulation and intravenous tyramine, and to elevated unstimulated heart rates. No significant changes are observed in plasma catecholamine responses to sympathetic stimulation, nor in β-adrenoreceptor numbers in heart ventricles. These findings suggest that the hypotensive effects of MAO inhibitors result from central nervous system rather than peripheral nervous system alterations.

Original languageEnglish (US)
Pages (from-to)155-160
Number of pages6
JournalEuropean Journal of Pharmacology
Volume80
Issue number1
DOIs
StatePublished - May 7 1982
Externally publishedYes

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Keywords

  • Blood pressure
  • Clorgyline
  • Deprenyl
  • Sympathetic stimulation
  • Tyramine
  • β-Adrenoreceptor

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Cohen, R. M., Campbell, I. C., Yamaguchi, I., Pickar, D., Kopin, I. J., & Murphy, D. L. (1982). Cardiovascular changes in response to selective monoamine oxidase inhibition in the rat. European Journal of Pharmacology, 80(1), 155-160. https://doi.org/10.1016/0014-2999(82)90193-5