Cardiospheres and cardiosphere-derived cells as therapeutic agents following myocardial infarction

Michelle Kreke, Rachel Ruckdeschel Smith, Linda Marbán, Eduardo Marbán

Research output: Contribution to journalArticle

Abstract

Heart disease is a major cause of morbidity and mortality. Cellular therapies hold significant promise for patients with heart disease. Heart-derived progenitor cells are capable of repairing a diseased heart through modulation of growth factor milieu and temporary engraftment leading to endogenous repair. The proof-of-concept CADUCEUS clinical trial using cardiosphere-derived cells has shown evidence of therapeutic cardiac tissue regeneration. Future clinical trials are now being planned to generate additional safety and efficacy data in the hopes of building toward an approved cellular therapy for heart disease.

Original languageEnglish (US)
Pages (from-to)1185-1194
Number of pages10
JournalExpert Review of Cardiovascular Therapy
Volume10
Issue number9
DOIs
StatePublished - Sep 2012
Externally publishedYes

Fingerprint

Heart Diseases
Myocardial Infarction
Clinical Trials
Therapeutics
Regeneration
Intercellular Signaling Peptides and Proteins
Stem Cells
Morbidity
Safety
Mortality

Keywords

  • allogeneic
  • autologous
  • cardiac tissue derived
  • cardiosphere-derived cells
  • cardiospheres
  • cellular therapy
  • heart disease
  • intracoronary infusion
  • intramuscular injection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Cardiospheres and cardiosphere-derived cells as therapeutic agents following myocardial infarction. / Kreke, Michelle; Smith, Rachel Ruckdeschel; Marbán, Linda; Marbán, Eduardo.

In: Expert Review of Cardiovascular Therapy, Vol. 10, No. 9, 09.2012, p. 1185-1194.

Research output: Contribution to journalArticle

Kreke, Michelle ; Smith, Rachel Ruckdeschel ; Marbán, Linda ; Marbán, Eduardo. / Cardiospheres and cardiosphere-derived cells as therapeutic agents following myocardial infarction. In: Expert Review of Cardiovascular Therapy. 2012 ; Vol. 10, No. 9. pp. 1185-1194.
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