Cardiospheres and cardiosphere-derived cells as therapeutic agents following myocardial infarction

Michelle Kreke; Rachel Ruckdeschel Smith; Linda Marbán; Eduardo Marbán

doi:10.1586/erc.12.102

Cardiospheres and cardiosphere-derived cells as therapeutic agents following myocardial infarction

Michelle Kreke, Rachel Ruckdeschel Smith, Linda Marbán, Eduardo Marbán

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Heart disease is a major cause of morbidity and mortality. Cellular therapies hold significant promise for patients with heart disease. Heart-derived progenitor cells are capable of repairing a diseased heart through modulation of growth factor milieu and temporary engraftment leading to endogenous repair. The proof-of-concept CADUCEUS clinical trial using cardiosphere-derived cells has shown evidence of therapeutic cardiac tissue regeneration. Future clinical trials are now being planned to generate additional safety and efficacy data in the hopes of building toward an approved cellular therapy for heart disease.

Original language	English (US)
Pages (from-to)	1185-1194
Number of pages	10
Journal	Expert Review of Cardiovascular Therapy
Volume	10
Issue number	9
DOIs	https://doi.org/10.1586/erc.12.102
State	Published - Sep 2012
Externally published	Yes

Keywords

allogeneic
autologous
cardiac tissue derived
cardiosphere-derived cells
cardiospheres
cellular therapy
heart disease
intracoronary infusion
intramuscular injection

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Internal Medicine

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10.1586/erc.12.102

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abstract = "Heart disease is a major cause of morbidity and mortality. Cellular therapies hold significant promise for patients with heart disease. Heart-derived progenitor cells are capable of repairing a diseased heart through modulation of growth factor milieu and temporary engraftment leading to endogenous repair. The proof-of-concept CADUCEUS clinical trial using cardiosphere-derived cells has shown evidence of therapeutic cardiac tissue regeneration. Future clinical trials are now being planned to generate additional safety and efficacy data in the hopes of building toward an approved cellular therapy for heart disease.",

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AU - Marbán, Eduardo

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AB - Heart disease is a major cause of morbidity and mortality. Cellular therapies hold significant promise for patients with heart disease. Heart-derived progenitor cells are capable of repairing a diseased heart through modulation of growth factor milieu and temporary engraftment leading to endogenous repair. The proof-of-concept CADUCEUS clinical trial using cardiosphere-derived cells has shown evidence of therapeutic cardiac tissue regeneration. Future clinical trials are now being planned to generate additional safety and efficacy data in the hopes of building toward an approved cellular therapy for heart disease.

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Cardiospheres and cardiosphere-derived cells as therapeutic agents following myocardial infarction

Abstract

Keywords

ASJC Scopus subject areas

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