Cardiorespiratory fitness and risk of incident atrial fibrillation results from the henry ford exercise testing (FIT) project

Waqas T. Qureshi, Zaid Alirhayim, Michael Blaha, Stephen P. Juraschek, Steven J. Keteyian, Clinton A. Brawner, Mouaz H. Al-Mallah

Research output: Contribution to journalArticle

Abstract

Background-Poor cardiorespiratory fitness (CRF) is an independent risk factor for cardiovascular morbidity and mortality. However, the relationship between CRF and atrial fibrillation (AF) is less clear. The aim of this analysis was to investigate the association between CRF and incident AF in a large, multiracial cohort that underwent graded exercise treadmill testing. Methods and Results-From 1991 to 2009, a total of 64 561 adults (mean age, 54.5±12.7 years; 46% female; 64% white) without AF underwent exercise treadmill testing at a tertiary care center. Baseline demographic and clinical variables were collected. Incident AF was ascertained by use of International Classification of Diseases, Ninth Revision code 427.31 and confirmed by linkage to medical claim files. Nested, multivariable Cox proportional hazards models were used to estimate the independent association of CRF with incident AF. During a median follow-up of 5.4 years (interquartile range, 3-9 years), 4616 new cases of AF were diagnosed. After adjustment for potential confounders, 1 higher metabolic equivalent achieved during treadmill testing was associated with a 7% lower risk of incident AF (hazard ratio, 0.93; 95% confidence interval, 0.92-0.94; P

Original languageEnglish (US)
Pages (from-to)1827-1834
Number of pages8
JournalCirculation
Volume131
Issue number21
DOIs
Publication statusPublished - May 26 2015

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Keywords

  • Atrial fibrillation
  • Exercise
  • Prevention and control

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Qureshi, W. T., Alirhayim, Z., Blaha, M., Juraschek, S. P., Keteyian, S. J., Brawner, C. A., & Al-Mallah, M. H. (2015). Cardiorespiratory fitness and risk of incident atrial fibrillation results from the henry ford exercise testing (FIT) project. Circulation, 131(21), 1827-1834. https://doi.org/10.1161/CIRCULATIONAHA.114.014833