TY - JOUR
T1 - Cardiopulmonary toxicity after liposomal amphotericin B infusion
AU - Levine, Stewart J.
AU - Walsh, Thomas J.
AU - Martinez, Anthony
AU - Eichacker, Peter Q.
AU - Lopez-Berestein, Gabriel
AU - Natanson, Charles
PY - 1991/4/15
Y1 - 1991/4/15
N2 - Liposomal and lipid complex drug delivery systems are being developed to enhance the therapeutic activity, decrease toxicity, and provide site-specific delivery of high doses of amphotericin B. Toxic reactions associated with liposomal amphotericin B therapy in humans have been limited to fever, chills, nausea, and electrolyte disturbances. This report supplements the known toxicities by describing transient, but reproducible, hypoxemia, pulmonary hypertension, and depression of cardiac output in a 22-year-old woman with lymphoblastic lymphoma who required liposomal amphotericin B for therapy of hepatosplenic candidiasis. Although liposomal drug delivery is a promising new approach to various disorders, its potential cardiopulmonary complications must enter into the decision regarding the dose, duration of infusion, and liposomal preparation to be used in individual patients.
AB - Liposomal and lipid complex drug delivery systems are being developed to enhance the therapeutic activity, decrease toxicity, and provide site-specific delivery of high doses of amphotericin B. Toxic reactions associated with liposomal amphotericin B therapy in humans have been limited to fever, chills, nausea, and electrolyte disturbances. This report supplements the known toxicities by describing transient, but reproducible, hypoxemia, pulmonary hypertension, and depression of cardiac output in a 22-year-old woman with lymphoblastic lymphoma who required liposomal amphotericin B for therapy of hepatosplenic candidiasis. Although liposomal drug delivery is a promising new approach to various disorders, its potential cardiopulmonary complications must enter into the decision regarding the dose, duration of infusion, and liposomal preparation to be used in individual patients.
UR - http://www.scopus.com/inward/record.url?scp=0025784404&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025784404&partnerID=8YFLogxK
M3 - Article
C2 - 2003714
AN - SCOPUS:0025784404
SN - 0003-4819
VL - 114
SP - 664
EP - 666
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 8
ER -