Cardioprotection by intermittent fasting in rats

Ismayil Ahmet, Ruiqian Wan, Mark P. Mattson, Edward Lakatta, Mark Talan

Research output: Contribution to journalArticle

Abstract

Background - Intermittent fasting (IF), a dietary regimen in which food is available only every other day, increases the life span and reduces the incidence of age-associated diseases in rodents. We have reported neuroprotective effects of IF against ischemic injury of the brain. In this study, we examined the effects of IF on ischemic injury of the heart in rats. Methods and Results - After 3 months of IF or regular every-day feeding (control) diets started in 2-month-old rats, myocardial infarction (MI) was induced by coronary artery ligation. Twenty-four hours after MI, its size in the IF group was 2-fold smaller, the number of apoptotic myocytes in the area at risk was 4-fold less, and the inflammatory response was significantly reduced compared with the control diet group. Serial echocardiography revealed that during 10 weeks after MI (with continuation of the IF regimen), the left ventricular (LV) remodeling and MI expansion that were observed in the control diet group were absent in the IF group. In a subgroup of animals with similar MI size at 1 week after MI, further observation revealed less remodeling, better LV function, and no MI expansion in the IF group compared with the control group. Conclusions - IF protects the heart from ischemic injury and attenuates post-MI cardiac remodeling, likely via antiapoptotic and antiinflammatory mechanisms.

Original languageEnglish (US)
Pages (from-to)3115-3121
Number of pages7
JournalCirculation
Volume112
Issue number20
DOIs
StatePublished - Nov 2005
Externally publishedYes

Fingerprint

Fasting
Myocardial Infarction
Heart Injuries
Diet
Control Groups
Rodent Diseases
Ventricular Remodeling
Neuroprotective Agents
Left Ventricular Function
Brain Injuries
Muscle Cells
Ligation
Echocardiography
Coronary Vessels
Anti-Inflammatory Agents
Observation
Food
Incidence

Keywords

  • Apoptosis
  • Diet
  • Inflammation
  • Myocardial infarction
  • Remodeling

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Cardioprotection by intermittent fasting in rats. / Ahmet, Ismayil; Wan, Ruiqian; Mattson, Mark P.; Lakatta, Edward; Talan, Mark.

In: Circulation, Vol. 112, No. 20, 11.2005, p. 3115-3121.

Research output: Contribution to journalArticle

Ahmet, I, Wan, R, Mattson, MP, Lakatta, E & Talan, M 2005, 'Cardioprotection by intermittent fasting in rats', Circulation, vol. 112, no. 20, pp. 3115-3121. https://doi.org/10.1161/CIRCULATIONAHA.105.563817
Ahmet, Ismayil ; Wan, Ruiqian ; Mattson, Mark P. ; Lakatta, Edward ; Talan, Mark. / Cardioprotection by intermittent fasting in rats. In: Circulation. 2005 ; Vol. 112, No. 20. pp. 3115-3121.
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