Cardioprotection and altered mitochondrial adenine nucleotide transport

Charles Jr Steenbergen, Samarjit Das, Jason Su, Renee Wong, Elizabeth Murphy

Research output: Contribution to journalArticle

Abstract

It is becoming increasingly clear that mitochondrial dysfunction is critically important in myocardial ischemic injury, and that cardioprotective mechanisms must ultimately prevent or attenuate mitochondrial damage. Mitochondria are also essential for energy production, and therefore prevention of mitochondrial injury must not compromise oxidative phosphorylation during reperfusion. This review will focus on one mitochondrial mechanism of cardioprotection involving inhibition of adenine nucleotide transport across the outer mitochondria membrane under de-energized conditions. This slows ATP hydrolysis by the mitochondria, and would be expected to lower mitochondrial membrane potential during ischemia, to inhibit calcium uptake during ischemia, and potentially to reduce free radical generation during early reperfusion. Two interventions that similarly inhibit mitochondrial adenine nucleotide transport are Bcl-2 overexpression and GSK inhibition. A possible final common mechanism shared by both of these interventions is discussed.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalBasic Research in Cardiology
Volume104
Issue number2
DOIs
StatePublished - 2009

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Adenine Nucleotides
Mitochondria
Reperfusion
Ischemia
Mitochondrial Membrane Potential
Oxidative Phosphorylation
Wounds and Injuries
Free Radicals
Hydrolysis
Adenosine Triphosphate
Calcium
Membranes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

Cite this

Cardioprotection and altered mitochondrial adenine nucleotide transport. / Steenbergen, Charles Jr; Das, Samarjit; Su, Jason; Wong, Renee; Murphy, Elizabeth.

In: Basic Research in Cardiology, Vol. 104, No. 2, 2009, p. 149-156.

Research output: Contribution to journalArticle

Steenbergen, Charles Jr ; Das, Samarjit ; Su, Jason ; Wong, Renee ; Murphy, Elizabeth. / Cardioprotection and altered mitochondrial adenine nucleotide transport. In: Basic Research in Cardiology. 2009 ; Vol. 104, No. 2. pp. 149-156.
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