Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility

Adriana Blazeski, Renjun Zhu, David W. Hunter, Seth H. Weinberg, Elias T. Zambidis, Leslie Tung

Research output: Contribution to journalReview articlepeer-review

Abstract

Since the first description of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), these cells have garnered tremendous interest for their potential use in patient-specific analysis and therapy. Additionally, hiPSC-CMs can be derived from donor cells from patients with specific cardiac disorders, enabling in vitro human disease models for mechanistic study and therapeutic drug assessment. However, a full understanding of their electrophysiological and contractile function is necessary before this potential can be realized. Here, we review this emerging field from a functional perspective, with particular emphasis on beating rate, action potential, ionic currents, multicellular conduction, calcium handling and contraction. We further review extant hiPSC-CM disease models that recapitulate genetic myocardial disease.

Original languageEnglish (US)
Pages (from-to)166-177
Number of pages12
JournalProgress in Biophysics and Molecular Biology
Volume110
Issue number2-3
DOIs
StatePublished - Oct 2012

Keywords

  • Cardiac cell
  • Contraction
  • Electrophysiology
  • Embryoid body
  • Human induced pluripotent stem cell
  • Optical mapping

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology

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