Cardiometabolic Risk Factors, Metabolic Syndrome, and Chronic Kidney Disease Progression in Children

Shwetal Lalan, Shuai Jiang, Derek K. Ng, Fernanda Kupferman, Bradley A. Warady, Susan Furth, Mark M. Mitsnefes

Research output: Contribution to journalArticlepeer-review


Objective: To estimate the prevalence of metabolic syndrome (MetS) and examine its association with chronic kidney disease progression in children enrolled in the Chronic Kidney Disease in Children study. Study design: MetS was defined as being overweight or obese and having ≥2 cardiometabolic risk factors (CMRFs). Incidence and prevalence of MetS were assessed using pairs of visits approximately 2 years apart. Results: A total of 799 pairs of person-visits (contributed by 472 children) were included in the final analysis. Of these, 70% had a normal body mass index (BMI), 14% were overweight, and 16% were obese. At the first visit, the prevalence of MetS in the overweight group was 40% and in the obese group was 60%. In adjusted models, annual percent estimated glomerular filtration rate decline in those who had normal BMI and incident or persistent multiple CMRFs or those with persistent MetS was −6.33%, −6.46%, and −6.08% (respectively) compared with children who never had multiple CMRFs (−3.38%, P =.048,.045, and.036, respectively). Children with normal BMI and incident multiple CMRFs and those with persistent MetS had approximately twice the odds of fast estimated glomerular filtration rate decline (>10% per year) compared with those without multiple CMRFs and normal BMI. Conclusion: Children with chronic kidney disease have a high prevalence of MetS. These children as well as those with normal BMI but multiple CMRFs experience a faster decline in kidney function.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalJournal of Pediatrics
StatePublished - Nov 2018


  • cardiovascular risk
  • children
  • chronic kidney disease
  • metabolic syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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